Coptisine chloride

盐酸黄连碱

Also known as: 6,7-Dihydro[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquino[3,2-a]isoquinolin-5-ium chloride, 6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium chloride, Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium, 6,7-dihydro-, chloride (1:1), Coptisine (chloride)

Coptisine chloride (CAS 6020-18-4) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C19H14ClNO4 and a molecular weight of 355.772 g/mol. It is also known as 6,7-Dihydro[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquino[3,2-a]isoquinolin-5-ium chloride, 6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium chloride and Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium, 6,7-dihydro-, chloride (1:1). Key properties include a melting point of >258ºC (dec.), a boiling point of 601.5ºC at 760 mmHg, a density of 1.51g/cm3 and a flash point of 190.4ºC. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 6020-18-4
Jingsj CID: J-30133-0
Molecular Formula: C₁₉H₁₄ClNO₄
Chinese Name: 盐酸黄连碱
Molecular Weight: 355.772 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	>258ºC (dec.)
Boiling Point	601.5ºC at 760 mmHg
Density	1.51g/cm3
Flash Point	190.4ºC
Exact Mass	355.061127
PSA	40.80000
Refractive Index	1.749

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed

Activity & Biological Data

Target	IDO:6.3 μM (IC50) IDO:5.8 μM (Ki)
Additional Information	[1]. Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302. [2]. He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94. [3]. Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565.

Target

IDO:6.3 μM (IC50) IDO:5.8 μM (Ki)

Additional Information

[1]. Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302. [2]. He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94. [3]. Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565.

Frequently Asked Questions

What is the CAS number of Coptisine chloride?

The CAS number of Coptisine chloride is 6020-18-4.

What are the molecular formula and molecular weight of Coptisine chloride?

Coptisine chloride has molecular formula C19H14ClNO4 and molecular weight 355.772 g/mol.

Is Coptisine chloride hazardous?

Coptisine chloride has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.

What are the upstream and downstream products of Coptisine chloride?

For Coptisine chloride, Upstream Products: Protopine, Berberine hydrochloride.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Coptisine chloride (CAS 6020-18-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-30133-0 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.