Protopine

Also known as: Biflorine, Biflorin, Corydinine, Fumarine, Hypercorine, Macleyine, Protopin, Tangeratin, 4,6,7,14-Tetrahydro-5-methyl-bis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-13(5H)-one, 7-Methyl-6,8,9,16-tetrahydrobis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-15(7H)-one

Protopine (CAS 130-86-9) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C20H19NO5 and a molecular weight of 353.369 g/mol. Key properties include a melting point of 211ºC, a boiling point of 547.5±49.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 284.9±29.8 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 130-86-9
Jingsj CID: J-18869-2
Molecular Formula: C₂₀H₁₉NO₅
Molecular Weight: 353.369 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	211ºC
Boiling Point	547.5±49.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	284.9±29.8 °C
Exact Mass	353.126312
PSA	57.23000
LogP	3.76
Vapor Pressure	0.0±1.5 mmHg at 25°C
Refractive Index	1.613
Storage Conditions	Refrigerator

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed

Activity & Biological Data

Additional Information	[1]. Bae DS, et al. Protopine reduces the inflammatory activity of lipopolysaccharide-stimulated murine macrophages. BMB Rep. 2012 Feb;45(2):108-13. [2]. Chen CH, et al. Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Cancer Lett. 2012 Feb 1;315(1):1-11. [3]. Vrba J, et al. Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR. Toxicol Lett. 2011 Jun 10;203(2):135-41. [4]. He K, et al. Protopine inhibits heterotypic cell adhesion in MDA-MB-231 cells through down-regulation of multi-adhesive factors. Afr J Tradit Complement Altern Med. 2014 Jan 28;11(2):415-24.

Additional Information

[1]. Bae DS, et al. Protopine reduces the inflammatory activity of lipopolysaccharide-stimulated murine macrophages. BMB Rep. 2012 Feb;45(2):108-13. [2]. Chen CH, et al. Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Cancer Lett. 2012 Feb 1;315(1):1-11. [3]. Vrba J, et al. Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR. Toxicol Lett. 2011 Jun 10;203(2):135-41. [4]. He K, et al. Protopine inhibits heterotypic cell adhesion in MDA-MB-231 cells through down-regulation of multi-adhesive factors. Afr J Tradit Complement Altern Med. 2014 Jan 28;11(2):415-24.

Frequently Asked Questions

What is the CAS number of Protopine?

The CAS number of Protopine is 130-86-9.

What are the molecular formula and molecular weight of Protopine?

Protopine has molecular formula C20H19NO5 and molecular weight 353.369 g/mol.

Is Protopine hazardous?

Protopine has GHS signal word Danger and hazard statements H301 — Toxic if swallowed.

What are the upstream and downstream products of Protopine?

For Protopine, Upstream Products: (6-Bromo-1,3-benzodioxol-5-yl)methanol, 5-Bromo-6-(chloromethyl)benzo[d][1,3]dioxole; Downstream Products: Coptisine, Dihydrosanguinarine, Sanguinarine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Protopine (CAS 130-86-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-18869-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.