Berberine hydrochloride

Also known as: Berberine chloride, Berberine HCl, Natural Yellow 18, Natural Yellow 18 chloride, Umbellatine, TIMTEC-BB SBB006488

Berberine hydrochloride (CAS 633-65-8) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C20H18ClNO4 and a molecular weight of 372.82 g/mol. Key properties include a melting point of 200ºC and a density of 1.654g/cm3. It is listed by 1 supplier, from 1.70 to 1.92 CNY. Record last updated Aug 21, 2026.

CAS No.: 633-65-8
Jingsj CID: J-1114659-7
Molecular Formula: C₂₀H₁₈ClNO₄
Molecular Weight: 372.82 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Supplier	Purity / Pack	Base Price	Unit Price	Origin
Maikuo Made to Order	97% 100g	¥170.00	$0.25 /gBest ¥1.70/g CNY	CN China MOQ 100g	View Product
Maikuo Made to Order	97% 500g	¥860.00	$0.26 /g ¥1.72/g CNY	CN China MOQ 500g	View Product
Maikuo In Stock	97% 250g	¥480.00	$0.29 /g ¥1.92/g CNY	CN China MOQ 5g	Visit Website

Physicochemical Properties

Melting Point	200ºC
Density	1.654g/cm3
Exact Mass	372.099701
PSA	40.80000
LogP	0.10030
Additional Property	SOLUBLE IN COLD WATER
SMILES	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]
InChIKey	VKJGBAJNNALVAV-UHFFFAOYSA-M
InChI	1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1

Activity & Biological Data

Additional Information	[1]. Jabbarzadeh Kaboli P, et al. Targets and mechanisms of berberine, a natural drug with potential to treat cancer with special focus on breast cancer. Eur J Pharmacol. 2014 Jun 26. pii: S0014-2999(14)00467-1. [2]. Wang Y, et al. Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption. Metabolism. 2014 Jun 4. pii: S0026-0495(14)00162-0. [3]. Yu R, et al. Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation. Cancer Cell Int. 2014 Jun 11;14:49. [4]. Albring KF, et al. Berberine acts as a natural inhibitor of Wnt/β-catenin signaling--identification of more active 13-arylalkyl derivatives. Biofactors. 2013 Nov-Dec;39(6):652-62.

Additional Information

[1]. Jabbarzadeh Kaboli P, et al. Targets and mechanisms of berberine, a natural drug with potential to treat cancer with special focus on breast cancer. Eur J Pharmacol. 2014 Jun 26. pii: S0014-2999(14)00467-1. [2]. Wang Y, et al. Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption. Metabolism. 2014 Jun 4. pii: S0026-0495(14)00162-0. [3]. Yu R, et al. Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation. Cancer Cell Int. 2014 Jun 11;14:49. [4]. Albring KF, et al. Berberine acts as a natural inhibitor of Wnt/β-catenin signaling--identification of more active 13-arylalkyl derivatives. Biofactors. 2013 Nov-Dec;39(6):652-62.

Customs & Trade Information

HS Code	3003409000

Frequently Asked Questions

What is the CAS number of Berberine hydrochloride?

The CAS number of Berberine hydrochloride is 633-65-8.

What are the molecular formula and molecular weight of Berberine hydrochloride?

Berberine hydrochloride has molecular formula C20H18ClNO4 and molecular weight 372.82 g/mol.

Which suppliers offer Berberine hydrochloride?

1 supplier(s) listed; reference unit price ¥1.70–1.92 /g.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Berberine hydrochloride (CAS 633-65-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1114659-7 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.