Imipramine

Also known as: IM, Tofranil, Melipramin, Melipramine, Imipramina, Imizin, Imizine, Imiprin, Imizinum, Impramine, Intalpram, Berkomine, Dimipressin, Nelipramin, Antideprin, Imidobenzyle, 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine, 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine, [14C]-Imipramine, [3H]-Imipramine

Imipramine (CAS 50-49-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C19H24N2 and a molecular weight of 280.40700 g/mol. Key properties include a melting point of 174°C, a boiling point of 403.1ºC at 760mmHg, a density of 1.041g/cm3 and a flash point of 179.7ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 50-49-7
Jingsj CID: J-22988-9
Molecular Formula: C₁₉H₂₄N₂
Molecular Weight: 280.40700 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	174°C
Boiling Point	403.1ºC at 760mmHg
Density	1.041g/cm3
Flash Point	179.7ºC
Exact Mass	280.19400
PSA	6.48000
LogP	3.94000
Refractive Index	1.574

Activity & Biological Data

Target	Fascin1, Autophagy, Apoptosis[1][2][3]
Additional Information	[1]. Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52(2):281-292. [2]. Jeon SH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun. 2011 Sep 23;413(2):311-7. [3]. Xia Z, et al. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. [4]. Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20.

Target

Fascin1, Autophagy, Apoptosis[1][2][3]

Additional Information

[1]. Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52(2):281-292. [2]. Jeon SH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun. 2011 Sep 23;413(2):311-7. [3]. Xia Z, et al. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. [4]. Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Imipramine?

The CAS number of Imipramine is 50-49-7.

What are the molecular formula and molecular weight of Imipramine?

Imipramine has molecular formula C19H24N2 and molecular weight 280.40700 g/mol.

What are the upstream and downstream products of Imipramine?

For Imipramine, Upstream Products: Iminodibenzyl, 3-Chloro-N,N-dimethylpropan-1-amine, Imipramine N-oxide; Downstream Products: Desipramine hydrochloride, Imipramine N-oxide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Imipramine (CAS 50-49-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-22988-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.