Desipramine hydrochloride

Also known as: Desipramine HCl, Desimipramine Hydrochloride, 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine hydrochloride, 5-[3-(Methylamino)propyl]-5H-dibenz[b,f]azepine hydrochloride, N-(γ-Methylaminopropyl)iminodibenzyl hydrochloride, RMI 9384A, MFCD00058108, EINECS 200-373-1

Desipramine hydrochloride (CAS 58-28-6) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C18H23ClN2 and a molecular weight of 302.842 g/mol. Key properties include a melting point of 214-216ºC, a boiling point of 407.4ºC at 760 mmHg and a flash point of 160.5ºC. It is classified under GHS with signal word Danger and hazard statements H225 — Highly flammable liquid and vapour, H301 — Toxic if swallowed and H311 — Toxic in contact with skin. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 58-28-6
Jingsj CID: J-31047-4
Molecular Formula: C₁₈H₂₃ClN₂
Molecular Weight: 302.842 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	214-216ºC
Boiling Point	407.4ºC at 760 mmHg
Flash Point	160.5ºC
Exact Mass	302.154968
PSA	15.27000
LogP	4.79070
Storage Conditions	2-8°C
Additional Property	H2O: 50 mg/mL

GHS Safety & Compliance

Flammable / Acute Toxicity / Health HazardSignal word: Danger

H225 — Highly flammable liquid and vapour
H301 — Toxic if swallowed
H311 — Toxic in contact with skin
H331 — Toxic if inhaled
H370 — Causes damage to organs

Activity & Biological Data

Target	Ki: 4 nM (NET), 61 nM (SERT), 78720 nM (DAT)[1]
Additional Information	[1]. Torres GE, et al. Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci. 2003 Jan;4(1):13-25. [2]. Zhao Z, et al. Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacology. 2008 Dec;33(13):3190-200.

Frequently Asked Questions

What is the CAS number of Desipramine hydrochloride?

The CAS number of Desipramine hydrochloride is 58-28-6.

What are the molecular formula and molecular weight of Desipramine hydrochloride?

Desipramine hydrochloride has molecular formula C18H23ClN2 and molecular weight 302.842 g/mol.

Is Desipramine hydrochloride hazardous?

Desipramine hydrochloride has GHS signal word Danger and hazard statements H225 — Highly flammable liquid and vapour; H301 — Toxic if swallowed; H311 — Toxic in contact with skin.

What are the upstream and downstream products of Desipramine hydrochloride?

For Desipramine hydrochloride, Downstream Products: Iminodibenzyl, Desipramine hydrochloride, Imipramine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Desipramine hydrochloride (CAS 58-28-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-31047-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.