Losartan carboxylic acid
氯沙坦羧酸
Also known as: EXP 3174, E-3174, EXP3174, Exp3174, 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl)methyl]-1H-imidazole-5-carboxylic acid, 2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylic acid, 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid, Losartan acid, Losartan carboxylic acid, AKOS 91941, Carboxylosartan
Losartan carboxylic acid (CAS 124750-92-1) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C22H21ClN6O2 and a molecular weight of 436.894 g/mol. It is also known as EXP 3174, E-3174 and EXP3174. Key properties include a melting point of 130-132ºC, a boiling point of 707.8±70.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 381.8±35.7 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 124750-92-1
- Jingsj CID
- J-1959782-1
- Molecular Formula
- C22H21ClN6O2
- Chinese Name
- 氯沙坦羧酸
- Molecular Weight
- 436.894 g/mol
- Category
- Organic Acids
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 130-132ºC |
|---|---|
| Boiling Point | 707.8±70.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 381.8±35.7 °C |
| Exact Mass | 436.141449 |
| PSA | 109.58000 |
| LogP | 4.79 |
| Vapor Pressure | 0.0±2.4 mmHg at 25°C |
| Refractive Index | 1.695 |
| Storage Conditions | -20°C Freezer |
Activity & Biological Data
| Target | Angiotensin II receptor type 1[1] |
|---|---|
| Additional Information | [1]. Sachinidis A, et al. EXP3174, a metabolite of losartan (MK 954, DuP 753) is more potent than losartan in blockingthe angiotensin II-induced responses in vascular smooth muscle cells. J Hypertens. 1993 Feb;11(2):155-62. [2]. Inada Y, et al. Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors. Fundam Clin Pharmacol. 2002 Aug;16(4):317-23. [3]. Richard V, et al. Comparison of the effects of EXP3174, an angiotensin II antagonist and enalaprilat on myocardial infarct size in anaesthetized dogs. Br J Pharmacol. 1993 Nov;110(3):969-74. [4]. Lynch JJ Jr, et al. EXP3174, the AII antagonist human metabolite of losartan, but not losartan nor the angiotensin-converting enzyme inhibitor captopril, prevents the development of lethal ischemic ventricular arrhythmias in a canine model of recent myocardial infarction. J Am Coll Cardiol. 1999 Sep;34(3):876-84. |
Frequently Asked Questions
What is the CAS number of Losartan carboxylic acid?
The CAS number of Losartan carboxylic acid is 124750-92-1.
What are the molecular formula and molecular weight of Losartan carboxylic acid?
Losartan carboxylic acid has molecular formula C22H21ClN6O2 and molecular weight 436.894 g/mol.
What are the upstream and downstream products of Losartan carboxylic acid?
For Losartan carboxylic acid, Upstream Products: Losartan potassium, Losartan; Downstream Products: 1,3-Dicyclohexylurea.
Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Losartan carboxylic acid (CAS 124750-92-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959782-1 (accessed 2026-10-28).
Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.