Losartan potassium

Also known as: Losartan potassium salt, Cozaar, DuP 753, MK-954, 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol monopotassium salt, Potassium 5-(4'-{[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl}biphenyl-2-yl)tetrazol-1-ide, Aradois, Losaprex, Lortaan

Losartan potassium (CAS 124750-99-8) is a compound in the Organohalogen Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H22ClKN6O and a molecular weight of 461.001 g/mol. Key properties include a melting point of −69 °C(lit.), a boiling point of 134 °C(lit.), a density of 0.986 g/mL at 25 °C(lit.) and a flash point of 24.4 °C. No supplier offers are currently listed; request a quote. Record last updated Nov 2, 2026.

CAS No.: 124750-99-8
Jingsj CID: J-1095684-3
Molecular Formula: C₂₂H₂₂ClKN₆O
Molecular Weight: 461.001 g/mol
Category: Organohalogen Compounds
Last updated: 11/2/2026

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Physicochemical Properties

Melting Point	−69 °C(lit.)
Boiling Point	134 °C(lit.)
Density	0.986 g/mL at 25 °C(lit.)
Flash Point	24.4 °C
Exact Mass	460.118073
PSA	89.61000
LogP	3.89590
Vapor Pressure	1.55E-19mmHg at 25°C
Refractive Index	n20/D 1.387(lit.)
Storage Conditions	Desiccate at RT

Activity & Biological Data

Target	IC50: 20 nM (angiotensin II)
Additional Information	[1]. Burnier, M. Angiotensin II type 1 receptor blockers. Circulation, 2001. 103(6): p. 904-12. [2]. Ashry, O., et al. Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respir Physiol Neurobiol, 2014. [3]. Choi, C.H., et al. Angiotensin II type I receptor and miR-155 in endometrial cancers: synergistic antiproliferative effects of anti-miR-155 and losartan on endometrial cancer cells. Gynecol Oncol, 2012. 126(1): p. 124-31. [4]. Habashi, J.P., et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science, 2006. 312(5770): p. 117-21. [5]. Campbell, D.J., et al. Effects of losartan on angiotensin and bradykinin peptides and angiotensin-converting enzyme. J Cardiovasc Pharmacol, 1995. 26(2): p. 233-40.

Target

IC50: 20 nM (angiotensin II)

Additional Information

[1]. Burnier, M. Angiotensin II type 1 receptor blockers. Circulation, 2001. 103(6): p. 904-12. [2]. Ashry, O., et al. Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respir Physiol Neurobiol, 2014. [3]. Choi, C.H., et al. Angiotensin II type I receptor and miR-155 in endometrial cancers: synergistic antiproliferative effects of anti-miR-155 and losartan on endometrial cancer cells. Gynecol Oncol, 2012. 126(1): p. 124-31. [4]. Habashi, J.P., et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science, 2006. 312(5770): p. 117-21. [5]. Campbell, D.J., et al. Effects of losartan on angiotensin and bradykinin peptides and angiotensin-converting enzyme. J Cardiovasc Pharmacol, 1995. 26(2): p. 233-40.

Customs & Trade Information

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Losartan potassium?

The CAS number of Losartan potassium is 124750-99-8.

What are the molecular formula and molecular weight of Losartan potassium?

Losartan potassium has molecular formula C22H22ClKN6O and molecular weight 461.001 g/mol.

What are the upstream and downstream products of Losartan potassium?

For Losartan potassium, Upstream Products: [2-(1H-Tetrazol-5-yl)phenyl]boronic acid, 1-(4-Bromobenzyl)-2-butyl-4-chloro-1H-imidazole-5-methanol, Losartan; Downstream Products: Trityllosartan, Losartan carboxylic acid, Losartan Carboxaldehyde.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 11/2/2026

How to cite: Jingsj. "Losartan potassium (CAS 124750-99-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1095684-3 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.