Nobiletin

Also known as: 3',4',5,6,7,8-Hexamethoxyflavone, 5,6,7,8,3',4'-Hexamethoxyflavone, Hexamethoxyflavone, 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one, MFCD03273560

Nobiletin (CAS 478-01-3) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C21H22O8 and a molecular weight of 402.395 g/mol. Key properties include a melting point of 138 °C, a boiling point of 587.9±50.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 256.5±30.2 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 478-01-3
Jingsj CID: J-9897-5
Molecular Formula: C₂₁H₂₂O₈
Molecular Weight: 402.395 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	138 °C
Boiling Point	587.9±50.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	256.5±30.2 °C
Exact Mass	402.131470
PSA	85.59000
LogP	2.48
Vapor Pressure	0.0±1.6 mmHg at 25°C
Refractive Index	1.558
Storage Conditions	-20°C
Stability	Stable, but unstable if heated rapidly. Combustible. Incompatible with strong oxidizing agents, powdered aluminium, potassium.

Activity & Biological Data

Additional Information	[1]. Takito J, et al. Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells. Can J Physiol Pharmacol. 2016 Feb 12:1-6. [2]. He B, et al. The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab. 2016 Apr 12;23(4):610-21. [3]. Cheng HL, et al. Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression. Oncotarget. 2016 Apr 29.

Additional Information

[1]. Takito J, et al. Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells. Can J Physiol Pharmacol. 2016 Feb 12:1-6. [2]. He B, et al. The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab. 2016 Apr 12;23(4):610-21. [3]. Cheng HL, et al. Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression. Oncotarget. 2016 Apr 29.

Frequently Asked Questions

What is the CAS number of Nobiletin?

The CAS number of Nobiletin is 478-01-3.

What are the molecular formula and molecular weight of Nobiletin?

Nobiletin has molecular formula C21H22O8 and molecular weight 402.395 g/mol.

What are the upstream and downstream products of Nobiletin?

For Nobiletin, Upstream Products: Dimethyl sulfate, 3,4-Dimethoxybenzoyl chloride, 1,2,3-Trimethoxybenzene; Downstream Products: Gardenin B, Salvigenin, Artemetin.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Nobiletin (CAS 478-01-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-9897-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.