3,5,6,7,8,3',4'-Heptamethoxyflavone

Also known as: 3,3',4',5,6,7,8-Heptamethoxyflavone, 3',4',3,5,6,7,8-Heptamethoxyflavone, 3,5,6,7,8,3',4'-Heptamethoxyflavone, 2-(3,4-Dimethoxyphenyl)-3,5,6,7,8-pentamethoxy-4H-chromen-4-one, 2-(3,4-dimethoxyphenyl)-3,5,6,7,8-pentamethoxychromen-4-one, 3-Methoxynobiletin, Hepta-3, NSC 618928

3,5,6,7,8,3',4'-Heptamethoxyflavone (CAS 1178-24-1) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C22H24O9 and a molecular weight of 432.421 g/mol. Key properties include a boiling point of 618.7±55.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 268.0±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1178-24-1
Jingsj CID: J-39888-9
Molecular Formula: C₂₂H₂₄O₉
Molecular Weight: 432.421 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	618.7±55.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	268.0±31.5 °C
Exact Mass	432.142029
PSA	94.82000
LogP	1.59
Vapor Pressure	0.0±1.8 mmHg at 25°C
Refractive Index	1.576

Activity & Biological Data

Additional Information	[1]. Kim HI, et al. 3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Inhibits Collagenase Activity and Induces Type I Procollagen Synthesis in HDFn Cells. Int J Mol Sci. 2018 Feb 22;19(2). [2]. Iwase Y, et al. Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants. Cancer Lett. 2001 Feb 10;163(1):7-9. [3]. Adhikari-Devkota A, et al. Anti-neuroinflammatory activities of extract and polymethoxyflavonoids from immature fruit peels of Citrus 'Hebesu'. J Food Biochem. 2019 Jun;43(6):e12813. [4]. Sawamoto A, et al. Citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone induces BDNF via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells. Pharmacol Rep. 2019 Aug;71(4):653-658.

Additional Information

[1]. Kim HI, et al. 3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Inhibits Collagenase Activity and Induces Type I Procollagen Synthesis in HDFn Cells. Int J Mol Sci. 2018 Feb 22;19(2). [2]. Iwase Y, et al. Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants. Cancer Lett. 2001 Feb 10;163(1):7-9. [3]. Adhikari-Devkota A, et al. Anti-neuroinflammatory activities of extract and polymethoxyflavonoids from immature fruit peels of Citrus 'Hebesu'. J Food Biochem. 2019 Jun;43(6):e12813. [4]. Sawamoto A, et al. Citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone induces BDNF via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells. Pharmacol Rep. 2019 Aug;71(4):653-658.

Customs & Trade Information

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of 3,5,6,7,8,3',4'-Heptamethoxyflavone?

The CAS number of 3,5,6,7,8,3',4'-Heptamethoxyflavone is 1178-24-1.

What are the molecular formula and molecular weight of 3,5,6,7,8,3',4'-Heptamethoxyflavone?

3,5,6,7,8,3',4'-Heptamethoxyflavone has molecular formula C22H24O9 and molecular weight 432.421 g/mol.

What are the upstream and downstream products of 3,5,6,7,8,3',4'-Heptamethoxyflavone?

For 3,5,6,7,8,3',4'-Heptamethoxyflavone, Upstream Products: Dimethyl sulfate, Sinensetin, Nobiletin; Downstream Products: Gardenin B, Salvigenin, Artemetin.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "3,5,6,7,8,3',4'-Heptamethoxyflavone (CAS 1178-24-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-39888-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.