5-Demethylnobiletin
Also known as: 5-Hydroxy-3',4',6,7,8-pentamethoxyflavone, 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone, 5-O-Demethylnobiletin, 5-Desmethylnobiletin, 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxychromen-4-one
5-Demethylnobiletin (CAS 2174-59-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C20H20O8 and a molecular weight of 388.368 g/mol. Key properties include a melting point of 145-146 ºC, a boiling point of 601.4±55.0 °C at 760 mmHg, a density of 1.304±0.06 g/cm3 and a flash point of 213.9±25.0 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 2174-59-6
- Jingsj CID
- J-1977708-3
- Molecular Formula
- C20H20O8
- Molecular Weight
- 388.368 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 145-146 ºC |
|---|---|
| Boiling Point | 601.4±55.0 °C at 760 mmHg |
| Density | 1.304±0.06 g/cm3 |
| Flash Point | 213.9±25.0 °C |
| Exact Mass | 388.115814 |
| PSA | 96.59000 |
| LogP | 2.10 |
| Vapor Pressure | 0.0±1.8 mmHg at 25°C |
| Refractive Index | 1.583 |
| Storage Conditions | 2-8C |
| Additional Property | Practically insoluble (0.058 g/L) (25 ºC) |
Activity & Biological Data
| Target | IC50: 0.1 μM (Lox 5); 0.35 μM (LTB4) (5-O-Demethylnobiletin)[1] |
|---|---|
| Additional Information | [1]. Bas E, et al. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Planta Med. 2006 Feb;72(2):136-42. [2]. Chiu SP, et al. Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. J Agric Food Chem. 2013 Oct 2;61(39):9453-63. |
Customs & Trade Information
| HS Code | 2914509090 |
|---|---|
| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
Frequently Asked Questions
What is the CAS number of 5-Demethylnobiletin?
The CAS number of 5-Demethylnobiletin is 2174-59-6.
What are the molecular formula and molecular weight of 5-Demethylnobiletin?
5-Demethylnobiletin has molecular formula C20H20O8 and molecular weight 388.368 g/mol.
What are the upstream and downstream products of 5-Demethylnobiletin?
For 5-Demethylnobiletin, Upstream Products: Nobiletin, 3,4-Dimethoxybenzoyl chloride, 1,2,3-Trimethoxybenzene; Downstream Products: Nobiletin.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "5-Demethylnobiletin (CAS 2174-59-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1977708-3 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.