Nimesulide

Also known as: 4-nitro-2-phenoxymethanesulfonanilide, N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide, N-(2-phenoxy-4-nitrophenyl)methanesulfonamide, N-(4-Nitro-2-phenoxy-phenyl)-methanesulfonamide, AULIN, Antifloxil, Flogovital, Guaxan, Mesulid, Nimed, Nimepast, Nisulid, Sulidene, R-805, EINECS 257-431-4, MFCD00079470

Nimesulide (CAS 51803-78-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C13H12N2O5S and a molecular weight of 308.310 g/mol. Key properties include a melting point of 140-146°C, a boiling point of 442.0±55.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 221.1±31.5 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 51803-78-2
Jingsj CID: J-33485-0
Molecular Formula: C₁₃H₁₂N₂O₅S
Molecular Weight: 308.310 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	140-146°C
Boiling Point	442.0±55.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	221.1±31.5 °C
Exact Mass	308.046692
PSA	109.60000
LogP	3.79
Vapor Pressure	0.0±1.1 mmHg at 25°C
Refractive Index	1.638

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed

Activity & Biological Data

Target	COX-2:0.07-70 μM (IC50)
Additional Information	[1]. Vago T, et al. Effect of nimesulide action time dependence on selectivity towards prostaglandin G/H synthase/cyclooxygenase activity. Arzneimittelforschung. 1995 Oct;45(10):1096-8. [2]. Werner MF, et al. Nimesulide-induced antipyresis in rats involves both cyclooxygenase-dependent and independent mechanisms. Eur J Pharmacol. 2006 Aug 14;543(1-3):181-9. [3]. Genç S, et al. The effect of COX-2 inhibitor, nimesulide, on angiogenetic factors in primary endometrial carcinoma cell culture. Clin Exp Med. 2007 Mar;7(1):6-10.

Target

COX-2:0.07-70 μM (IC50)

Additional Information

[1]. Vago T, et al. Effect of nimesulide action time dependence on selectivity towards prostaglandin G/H synthase/cyclooxygenase activity. Arzneimittelforschung. 1995 Oct;45(10):1096-8. [2]. Werner MF, et al. Nimesulide-induced antipyresis in rats involves both cyclooxygenase-dependent and independent mechanisms. Eur J Pharmacol. 2006 Aug 14;543(1-3):181-9. [3]. Genç S, et al. The effect of COX-2 inhibitor, nimesulide, on angiogenetic factors in primary endometrial carcinoma cell culture. Clin Exp Med. 2007 Mar;7(1):6-10.

Frequently Asked Questions

What is the CAS number of Nimesulide?

The CAS number of Nimesulide is 51803-78-2.

What are the molecular formula and molecular weight of Nimesulide?

Nimesulide has molecular formula C13H12N2O5S and molecular weight 308.310 g/mol.

Is Nimesulide hazardous?

Nimesulide has GHS signal word Danger and hazard statements H301 — Toxic if swallowed.

What are the upstream and downstream products of Nimesulide?

For Nimesulide, Upstream Products: N-(2-Phenoxyphenyl)methanesulfonamide; Downstream Products: Propyl 4-hydroxybenzoate, Phenacetin, Methylparaben.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Nimesulide (CAS 51803-78-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-33485-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.