Timegadine

替美加定

Also known as: 1-Cyclohexyl-2-(2-methyl-4-quinolyl)-3-(2-thiazolyl)guanidine, 2-cyclohexyl-1-(2-methylquinolin-4-yl)-3-(1,3-thiazol-2-yl)guanidine, N-Cyclohexyl-N''-(2-methylquinol-4-yl)-N'-2-thiazolylguanidine, N-Cyclohexyl-N'-(2-methyl-4-quinolyl)-N''-(2-thiazolyl)guanidine, Guanidine, N-cyclohexyl-N'-(2-methyl-4-quinolinyl)-N''-2-thiazolyl-, EINECS 275-184-0, SR1368, Timegadina [INN-Spanish], Timegadinum [INN-Latin]

Timegadine (CAS 71079-19-1) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C20H23N5S and a molecular weight of 365.49500 g/mol. It is also known as 1-Cyclohexyl-2-(2-methyl-4-quinolyl)-3-(2-thiazolyl)guanidine, 2-cyclohexyl-1-(2-methylquinolin-4-yl)-3-(1,3-thiazol-2-yl)guanidine and N-Cyclohexyl-N''-(2-methylquinol-4-yl)-N'-2-thiazolylguanidine. Key properties include a boiling point of 537.6ºC at 760 mmHg, a density of 1.31 g/cm3 and a flash point of 278.9ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 71079-19-1
Jingsj CID: J-1956190-1
Molecular Formula: C₂₀H₂₃N₅S
Chinese Name: 替美加定
Molecular Weight: 365.49500 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	537.6ºC at 760 mmHg
Density	1.31 g/cm3
Flash Point	278.9ºC
Exact Mass	365.16700
PSA	90.44000
LogP	5.48550
Refractive Index	1.701
Storage Conditions	2-8℃

Activity & Biological Data

Target	COX:5 nM (IC50, in rabbit platelets) COX:20 μM (IC50, in rat brain) lipo-oxygenase:100 μM (IC50, in horse and washed rabbit platelets)
Additional Information	[1]. George S, et al. The influence of food intake on the bioavailability of timegadine, a novel non-steroidal anti-inflammatory drug. Br J Clin Pharmacol. 1983 Apr;15(4):495-8. [2]. Ahnfelt-Rønne I, et al. A new antiinflammatory compound, timegadine (N-cyclohexyl-N"-4-[2-methylquinolyl]-N'-2-thiazolylguanidine), which inhibits both prostaglandin and 12-hydroxyeicosatetraenoic acid (12-HETE) formation. Biochem Pharmacol. 1980 Dec;29(24):3265-9.

Target

COX:5 nM (IC50, in rabbit platelets) COX:20 μM (IC50, in rat brain) lipo-oxygenase:100 μM (IC50, in horse and washed rabbit platelets)

Additional Information

[1]. George S, et al. The influence of food intake on the bioavailability of timegadine, a novel non-steroidal anti-inflammatory drug. Br J Clin Pharmacol. 1983 Apr;15(4):495-8. [2]. Ahnfelt-Rønne I, et al. A new antiinflammatory compound, timegadine (N-cyclohexyl-N"-4-[2-methylquinolyl]-N'-2-thiazolylguanidine), which inhibits both prostaglandin and 12-hydroxyeicosatetraenoic acid (12-HETE) formation. Biochem Pharmacol. 1980 Dec;29(24):3265-9.

Frequently Asked Questions

What is the CAS number of Timegadine?

The CAS number of Timegadine is 71079-19-1.

What are the molecular formula and molecular weight of Timegadine?

Timegadine has molecular formula C20H23N5S and molecular weight 365.49500 g/mol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Timegadine (CAS 71079-19-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1956190-1 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.