Flupirtine

Also known as: Ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate, D-9998, Katadolon, Effirma, Flupirtin, ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate

Flupirtine (CAS 56995-20-1) is a compound in the Organohalogen Compounds category listed in the Jingsj chemical database. It has the molecular formula C15H17FN4O2 and a molecular weight of 304.31900 g/mol. Key properties include a melting point of 115 - 116ºC, a boiling point of 434.9ºC at 760mmHg, a density of 1.35g/cm3 and a flash point of 216.8ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 56995-20-1
Jingsj CID: J-33718-2
Molecular Formula: C₁₅H₁₇FN₄O₂
Molecular Weight: 304.31900 g/mol
Category: Organohalogen Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	115 - 116ºC
Boiling Point	434.9ºC at 760mmHg
Density	1.35g/cm3
Flash Point	216.8ºC
Exact Mass	304.13400
PSA	89.27000
LogP	3.71060
Refractive Index	1.661
Storage Conditions	2-8℃

Activity & Biological Data

Additional Information	[1]. Kornhuber J, et al. Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltageindependent potassium channels. Rapid communication. J Neural Transm. 1999;106(9-10):857-67. [2]. Klinger F, et al. Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine. Br J Pharmacol. 2012 Jul;166(5):1631-42. [3]. Swedberg MD, et al. Pharmacological mechanisms of action of flupirtine: a novel, centrally acting, nonopioid analgesic evaluated by its discriminative effects in the rat. J Pharmacol Exp Ther. 1988 Sep;246(3):1067-74. [4]. Wu SN, et al. Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier k(+) currents in motor neuron-like cells. Evid Based Complement Alternat Med. 2012;2012:148403. [5]. Kolosov A, et al. Flupirtine enhances the anti-hyperalgesic effects of morphine in a rat model of prostate bone metastasis. Pain Med. 2012 Nov;13(11):1444-56. [6]. Michel MC, et al. Unexpected frequent hepatotoxicity of a prescription drug, flupirtine, marketed for about 30 years. Br J Clin Pharmacol. 2012 May;73(5):821-5.

Additional Information

[1]. Kornhuber J, et al. Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltageindependent potassium channels. Rapid communication. J Neural Transm. 1999;106(9-10):857-67. [2]. Klinger F, et al. Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine. Br J Pharmacol. 2012 Jul;166(5):1631-42. [3]. Swedberg MD, et al. Pharmacological mechanisms of action of flupirtine: a novel, centrally acting, nonopioid analgesic evaluated by its discriminative effects in the rat. J Pharmacol Exp Ther. 1988 Sep;246(3):1067-74. [4]. Wu SN, et al. Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier k(+) currents in motor neuron-like cells. Evid Based Complement Alternat Med. 2012;2012:148403. [5]. Kolosov A, et al. Flupirtine enhances the anti-hyperalgesic effects of morphine in a rat model of prostate bone metastasis. Pain Med. 2012 Nov;13(11):1444-56. [6]. Michel MC, et al. Unexpected frequent hepatotoxicity of a prescription drug, flupirtine, marketed for about 30 years. Br J Clin Pharmacol. 2012 May;73(5):821-5.

Frequently Asked Questions

What is the CAS number of Flupirtine?

The CAS number of Flupirtine is 56995-20-1.

What are the molecular formula and molecular weight of Flupirtine?

Flupirtine has molecular formula C15H17FN4O2 and molecular weight 304.31900 g/mol.

What are the upstream and downstream products of Flupirtine?

For Flupirtine, Upstream Products: 2,3-Diaminopyridine, 1',3'-dihydrospiro[cyclohexane-1,2'-[2H]imidazo[4,5-b]pyridine], 6-N-[(4-fluorophenyl)methyl]pyridine-2,3,6-triamine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Flupirtine (CAS 56995-20-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-33718-2 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.