PRIMA-1
Also known as: 1-Azabicyclo[2.2.2]octan-3-one, 2,2-bis(hydroxymethyl)-, 2,2-BIS(HYDROXYMETHYL)-1-AZABICYCLO[2,2,2]OCTAN-3-ONE, 2,2-BIS(HYDROXYMETHYL)-3-QUINUCLIDINONE, 2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one, 2,2-Bis(hydroxymethyl)quinuclidin-3-one, 2,2-Bis-methylol-3-chinuclidinon, 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one, 2,2-dimethylolquinuclidin-3-one, 2-Bis(hydroxymethyl)-3-quinuclidinone, 7,7-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-8-one, MFCD04974196, P53 REACTIVATION AND INDUCTION OF MASSIVE APOPTOSIS, PRIMA-1 - CAS 5608-24-2 - Calbiochem, Tocris-1862, p53 Reactivation and Induction of Massive Apoptosis, prima-1
PRIMA-1 (CAS 5608-24-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C9H15NO3 and a molecular weight of 185.220 g/mol. It is also known as 1-Azabicyclo[2.2.2]octan-3-one, 2,2-bis(hydroxymethyl)-, 2,2-BIS(HYDROXYMETHYL)-1-AZABICYCLO[2,2,2]OCTAN-3-ONE and 2,2-BIS(HYDROXYMETHYL)-3-QUINUCLIDINONE. Key properties include a boiling point of 353.7±17.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 167.7±20.9 °C. It is classified under GHS with signal word Danger and hazard statements H302 — Harmful if swallowed and H334 — May cause allergy or asthma symptoms if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 5608-24-2
- Jingsj CID
- J-45991-8
- Molecular Formula
- C9H15NO3
- Molecular Weight
- 185.220 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 353.7±17.0 °C at 760 mmHg |
|---|---|
| Density | 1.3±0.1 g/cm3 |
| Flash Point | 167.7±20.9 °C |
| Exact Mass | 185.105194 |
| PSA | 60.77000 |
| LogP | 0.70 |
| Vapor Pressure | 0.0±1.8 mmHg at 25°C |
| Refractive Index | 1.582 |
GHS Safety & Compliance
- H302 — Harmful if swallowed
- H334 — May cause allergy or asthma symptoms if inhaled
Activity & Biological Data
| Target | p53[1] |
|---|---|
| Additional Information | [1]. Cui B, et al. PRIMA-1, a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A. J Clin Endocrinol Metab. 2014 Jun;99(6):E962-70. [2]. Zhang Z, et al. Targeting cancer stem cells with p53 modulators. Oncotarget. 2016 Apr 8. [3]. Rao CV, et al. Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice. Neoplasia. 2013 Sep;15(9):1018-27. |
Frequently Asked Questions
What is the CAS number of PRIMA-1?
The CAS number of PRIMA-1 is 5608-24-2.
What are the molecular formula and molecular weight of PRIMA-1?
PRIMA-1 has molecular formula C9H15NO3 and molecular weight 185.220 g/mol.
Is PRIMA-1 hazardous?
PRIMA-1 has GHS signal word Danger and hazard statements H302 — Harmful if swallowed; H334 — May cause allergy or asthma symptoms if inhaled.
What are the upstream and downstream products of PRIMA-1?
For PRIMA-1, Upstream Products: Formaldehyde, 3-Quinuclidinone hydrochloride, 3-Quinuclidinone.
Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "PRIMA-1 (CAS 5608-24-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-45991-8 (accessed 2026-10-28).
Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.