Cyclopamine

Also known as: 11-Deoxojervine, Alkaloid V, (3β,22S,23R)-17,23-Epoxyveratraman-3-ol

Cyclopamine (CAS 4449-51-8) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C27H41NO2 and a molecular weight of 411.620 g/mol. Key properties include a melting point of 236-238ºC, a boiling point of 550.8±50.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 286.9±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 4449-51-8
Jingsj CID: J-1306835-4
Molecular Formula: C₂₇H₄₁NO₂
Molecular Weight: 411.620 g/mol
Category: Organic Bases
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	236-238ºC
Boiling Point	550.8±50.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	286.9±30.1 °C
Exact Mass	411.313721
PSA	41.49000
LogP	5.44
Vapor Pressure	0.0±3.4 mmHg at 25°C
Refractive Index	1.583
Additional Property	DMSO: soluble

Activity & Biological Data

Target	IC50: 46 nM (Hedgehog, in Hh cell assay)[1]
Additional Information	[1]. Peukert S, et al. Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway. Bioorg Med Chem Lett, 2009, 19(2), 328-331. [2]. Berman DM, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature, 2003, 425(6960), 846-851. [3]. Thayer SP, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature, 2003, 425(6960), 851-856. [4]. Ma W, et al. Reduced Smoothened level rescued Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease. J Genet Genomics. 2018 May 20;45(5):237-246.

Target

IC50: 46 nM (Hedgehog, in Hh cell assay)[1]

Additional Information

[1]. Peukert S, et al. Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway. Bioorg Med Chem Lett, 2009, 19(2), 328-331. [2]. Berman DM, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature, 2003, 425(6960), 846-851. [3]. Thayer SP, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature, 2003, 425(6960), 851-856. [4]. Ma W, et al. Reduced Smoothened level rescued Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease. J Genet Genomics. 2018 May 20;45(5):237-246.

Frequently Asked Questions

What is the CAS number of Cyclopamine?

The CAS number of Cyclopamine is 4449-51-8.

What are the molecular formula and molecular weight of Cyclopamine?

Cyclopamine has molecular formula C27H41NO2 and molecular weight 411.620 g/mol.

What are the upstream and downstream products of Cyclopamine?

For Cyclopamine, Upstream Products: Jervine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Cyclopamine (CAS 4449-51-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1306835-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.