Jervine

Also known as: Jervine, NSC 23898, Jervin, Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3β,23β)-, 11-Ketocyclopamine, (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one, (3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one, 17,23β-Epoxy-3β-hydroxyveratraman-11-one, Iervin

Jervine (CAS 469-59-0) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C27H39NO3 and a molecular weight of 425.603 g/mol. Key properties include a melting point of 242- 244ºC, a boiling point of 592.0±50.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 311.8±30.1 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 469-59-0
Jingsj CID: J-1987225-4
Molecular Formula: C₂₇H₃₉NO₃
Molecular Weight: 425.603 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	242- 244ºC
Boiling Point	592.0±50.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	311.8±30.1 °C
Exact Mass	425.292999
PSA	58.56000
LogP	3.46
Vapor Pressure	0.0±3.8 mmHg at 25°C
Refractive Index	1.591

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed

Activity & Biological Data

Additional Information	[1]. Incardona JP, et al. Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport. Dev Biol. 2000 Aug 15;224(2):440-52. [2]. Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6. [3]. Mistretta CM, et al. Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locations in dorsal lingual epithelium. D

Additional Information

[1]. Incardona JP, et al. Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport. Dev Biol. 2000 Aug 15;224(2):440-52. [2]. Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6. [3]. Mistretta CM, et al. Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locations in dorsal lingual epithelium. D

Frequently Asked Questions

What is the CAS number of Jervine?

The CAS number of Jervine is 469-59-0.

What are the molecular formula and molecular weight of Jervine?

Jervine has molecular formula C27H39NO3 and molecular weight 425.603 g/mol.

Is Jervine hazardous?

Jervine has GHS signal word Danger and hazard statements H301 — Toxic if swallowed.

What are the upstream and downstream products of Jervine?

For Jervine, Downstream Products: Cyclopamine, 2-Ethyl-5-methylpyridine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Jervine (CAS 469-59-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1987225-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.