4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Also known as: 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene, 4-Chloro-3-(trifluoromethyl)phenyl isocyanate, Isocyanic Acid 4-Chloro-3-(trifluoromethyl)phenyl Ester, Sorafenib intermediate 3, 4-Chloro-α,α,α-trifluoro-m-tolyl isocyanate, MFCD00013874

4-Chloro-3-(trifluoromethyl)phenyl isocyanate (CAS 327-78-6) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C8H3ClF3NO and a molecular weight of 221.564 g/mol. Key properties include a melting point of 40-42 °C(lit.), a boiling point of 201.7±0.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 99.4±0.0 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed, H312 — Harmful in contact with skin and H315 — Causes skin irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 327-78-6
Jingsj CID: J-936279-2
Molecular Formula: C₈H₃ClF₃NO
Molecular Weight: 221.564 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	40-42 °C(lit.)
Boiling Point	201.7±0.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	99.4±0.0 °C
Exact Mass	220.985519
PSA	29.43000
LogP	4.93
Vapor Pressure	0.3±0.3 mmHg at 25°C
Refractive Index	1.487

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed
H312 — Harmful in contact with skin
H315 — Causes skin irritation
H319 — Causes serious eye irritation
H332 — Harmful if inhaled
H335 — May cause respiratory irritation

Customs & Trade Information

HS Code	2929109000
Summary	2929109000. other isocyanates. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Frequently Asked Questions

What is the CAS number of 4-Chloro-3-(trifluoromethyl)phenyl isocyanate?

The CAS number of 4-Chloro-3-(trifluoromethyl)phenyl isocyanate is 327-78-6.

What are the molecular formula and molecular weight of 4-Chloro-3-(trifluoromethyl)phenyl isocyanate?

4-Chloro-3-(trifluoromethyl)phenyl isocyanate has molecular formula C8H3ClF3NO and molecular weight 221.564 g/mol.

Is 4-Chloro-3-(trifluoromethyl)phenyl isocyanate hazardous?

4-Chloro-3-(trifluoromethyl)phenyl isocyanate has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H312 — Harmful in contact with skin; H315 — Causes skin irritation.

What are the upstream and downstream products of 4-Chloro-3-(trifluoromethyl)phenyl isocyanate?

For 4-Chloro-3-(trifluoromethyl)phenyl isocyanate, Upstream Products: Bis(trichloromethyl) carbonate, 5-Amino-2-chlorobenzotrifluoride, Diphosgene; Downstream Products: Flucofuron, 4-Acetyl-4'-nitrodiphenyl ether, Regorafenib.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "4-Chloro-3-(trifluoromethyl)phenyl isocyanate (CAS 327-78-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-936279-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.