Regorafenib
Also known as: BAY 73-4506, Stivarga, 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide
Regorafenib (CAS 755037-03-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C21H15ClF4N4O3 and a molecular weight of 482.815 g/mol. Key properties include a melting point of 206.0 to 210.0 °C, a boiling point of 513.4±50.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 264.3±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 755037-03-7
- Jingsj CID
- J-1960042-1
- Molecular Formula
- C21H15ClF4N4O3
- Molecular Weight
- 482.815 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 206.0 to 210.0 °C |
|---|---|
| Boiling Point | 513.4±50.0 °C at 760 mmHg |
| Density | 1.5±0.1 g/cm3 |
| Flash Point | 264.3±30.1 °C |
| Exact Mass | 482.076874 |
| PSA | 92.35000 |
| LogP | 5.26 |
| Vapor Pressure | 0.0±1.3 mmHg at 25°C |
| Refractive Index | 1.616 |
Activity & Biological Data
| Target | VEGFR1:13 nM (IC50) VEGFR2:4.2 nM (IC50) VEGFR3:46 nM (IC50) PDGFRβ:22 nM (IC50) Raf-1:2.5 nM (IC50) Braf:28 nM (IC50) BRafV600E:19 nM (IC50) |
|---|---|
| Additional Information | [1]. Wilhelm SM, et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer, 2011, 129(1), 245-255. [2]. Heng DY, et al. Targeted therapy for metastatic renal cell carcinoma: current treatment and future directions. Ther Adv Med Oncol, 2010, 2(1), 39-49. [3]. Carr BI, et al. Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery. J Cell Physiol, 2013, 228(2), 292-297. [4]. Wagner J, et al. Anti-tumor effects of ONC201 in combination with VEGF-inhibitors significantly impacts colorectal cancer growth and survival in vivo through complementary non-overlapping mechanisms. J Exp Clin Cancer Res. 2018 Jan 22;37(1):11. [5]. Matsuoka K, et al. Effective Sequential Combined Chemotherapy with Trifluridine/Tipiracil and Regorafenib in Human Colorectal Cancer Cells. Int J Mol Sci. 2018 Sep 25;19(10). pii: E2915. |
Frequently Asked Questions
What is the CAS number of Regorafenib?
The CAS number of Regorafenib is 755037-03-7.
What are the molecular formula and molecular weight of Regorafenib?
Regorafenib has molecular formula C21H15ClF4N4O3 and molecular weight 482.815 g/mol.
What are the upstream and downstream products of Regorafenib?
For Regorafenib, Upstream Products: 4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide, 4-Chloro-3-(trifluoromethyl)phenyl isocyanate, 3-Fluoro-4-nitrophenol; Downstream Products: Regorafenib hydrochloride.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Regorafenib (CAS 755037-03-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1960042-1 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.