Sorafenib

Also known as: 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide, 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide, Bay 43-9006, BAY 43-9006, Nexavar

Sorafenib (CAS 284461-73-0) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C21H16ClF3N4O3 and a molecular weight of 464.825 g/mol. Key properties include a melting point of 202-204°C, a boiling point of 523.3±50.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 270.3±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 284461-73-0
Jingsj CID: J-1498039-3
Molecular Formula: C₂₁H₁₆ClF₃N₄O₃
Molecular Weight: 464.825 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	202-204°C
Boiling Point	523.3±50.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	270.3±30.1 °C
Exact Mass	464.086304
PSA	92.35000
LogP	5.16
Vapor Pressure	0.0±1.4 mmHg at 25°C
Refractive Index	1.626
Storage Conditions	-20°C Freezer

Activity & Biological Data

Target	VEGFR3:20 nM (IC50) Braf:22 nM (IC50) Raf-1:6 nM (IC50) VEGFR2:90 nM (IC50) PDGFRβ:57 nM (IC50) BrafV599E:38 nM (IC50) c-Kit:68 nM (IC50) Flt3:58 nM (IC50)
Additional Information	[1]. Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109. [2]. El-Ashmawy NE, et al. Sorafenib effect on liver neoplastic changes in rats: more than a kinase inhibitor. Clin Exp Med. 2016 Apr 16. [3]. Jin W, et al. Long non-coding RNA TUC338 is functionally involved in sorafenib-sensitized hepatocarcinoma cells by targeting RASAL1. Oncol Rep. 2017 Jan;37(1):273-280. [4]. Li M, et al. Activation of an AKT/FOXM1/STMN1 pathway drives resistance to tyrosine kinase inhibitors in lung cancer. Br J Cancer. 2017 Aug 29.

Target

VEGFR3:20 nM (IC50) Braf:22 nM (IC50) Raf-1:6 nM (IC50) VEGFR2:90 nM (IC50) PDGFRβ:57 nM (IC50) BrafV599E:38 nM (IC50) c-Kit:68 nM (IC50) Flt3:58 nM (IC50)

Additional Information

[1]. Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109. [2]. El-Ashmawy NE, et al. Sorafenib effect on liver neoplastic changes in rats: more than a kinase inhibitor. Clin Exp Med. 2016 Apr 16. [3]. Jin W, et al. Long non-coding RNA TUC338 is functionally involved in sorafenib-sensitized hepatocarcinoma cells by targeting RASAL1. Oncol Rep. 2017 Jan;37(1):273-280. [4]. Li M, et al. Activation of an AKT/FOXM1/STMN1 pathway drives resistance to tyrosine kinase inhibitors in lung cancer. Br J Cancer. 2017 Aug 29.

Frequently Asked Questions

What is the CAS number of Sorafenib?

The CAS number of Sorafenib is 284461-73-0.

What are the molecular formula and molecular weight of Sorafenib?

Sorafenib has molecular formula C21H16ClF3N4O3 and molecular weight 464.825 g/mol.

What are the upstream and downstream products of Sorafenib?

For Sorafenib, Upstream Products: 4-(4-Aminophenoxy)-N-methylpicolinamide, 4-Chloro-3-(trifluoromethyl)phenyl isocyanate, Phenyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Sorafenib (CAS 284461-73-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1498039-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.