Gemcitabine

Also known as: 2',2'-Difluorodeoxycytidine, 2'-Deoxy-2',2'-difluorocytidine, dFdC, 1-(2-deoxy-2,2-difluoro-β-D-erythropentofuranosyl)cytosine, 4-amino-1-(2-deoxy-2,2-difluoro-β-D-erythropentofuranosyl)pyrimidin-2(1H)-one, Cytidine, 2'-deoxy-2',2'-difluoro-, NSC 613327

Gemcitabine (CAS 95058-81-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C9H11F2N3O4 and a molecular weight of 263.198 g/mol. Key properties include a melting point of 168.64°C, a boiling point of 468.0±55.0 °C at 760 mmHg, a density of 1.8±0.1 g/cm3 and a flash point of 236.8±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 95058-81-4
Jingsj CID: J-47745-2
Molecular Formula: C₉H₁₁F₂N₃O₄
Molecular Weight: 263.198 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	168.64°C
Boiling Point	468.0±55.0 °C at 760 mmHg
Density	1.8±0.1 g/cm3
Flash Point	236.8±31.5 °C
Exact Mass	263.071747
PSA	110.60000
LogP	-1.24
Vapor Pressure	0.0±2.6 mmHg at 25°C
Refractive Index	1.652

Activity & Biological Data

Target	DNA synthesis[1]
Additional Information	[1]. Wang H, et al. Enhanced efficacy of Gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrativenucleoside transporter 1. Anticancer Res. 2011 Oct;31(10):3171-80. [2]. Yip-Schneider MT, et al. Dimethylaminoparthenolide and Gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer. BMC Cancer. 2013 Apr 17;13:194. [3]. Gagnadoux F, et al. Safety of pulmonary administration of gemcitabine in rats. J Aerosol Med. 2005 Summer;18(2):198-206 [4]. Lou M, et al. Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy. J Biol Chem. 2017 Jun 2;292(22):9136-9149. [5]. Wang Y, et al. Licoricidin enhances gemcitabine-induced cytotoxicity in osteosarcoma cells by suppressing the Akt and NF-κB signal pathways. Chem Biol Interact. 2018 May 18;290:44-51.

Target

DNA synthesis[1]

Additional Information

[1]. Wang H, et al. Enhanced efficacy of Gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrativenucleoside transporter 1. Anticancer Res. 2011 Oct;31(10):3171-80. [2]. Yip-Schneider MT, et al. Dimethylaminoparthenolide and Gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer. BMC Cancer. 2013 Apr 17;13:194. [3]. Gagnadoux F, et al. Safety of pulmonary administration of gemcitabine in rats. J Aerosol Med. 2005 Summer;18(2):198-206 [4]. Lou M, et al. Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy. J Biol Chem. 2017 Jun 2;292(22):9136-9149. [5]. Wang Y, et al. Licoricidin enhances gemcitabine-induced cytotoxicity in osteosarcoma cells by suppressing the Akt and NF-κB signal pathways. Chem Biol Interact. 2018 May 18;290:44-51.

Frequently Asked Questions

What is the CAS number of Gemcitabine?

The CAS number of Gemcitabine is 95058-81-4.

What are the molecular formula and molecular weight of Gemcitabine?

Gemcitabine has molecular formula C9H11F2N3O4 and molecular weight 263.198 g/mol.

What are the upstream and downstream products of Gemcitabine?

For Gemcitabine, Upstream Products: Gemcitabine hydrochloride, LY2334737; Downstream Products: 2'-Deoxy-2',2'-difluoro-5'-cytidylic acid, Gemcitabine hydrochloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Gemcitabine (CAS 95058-81-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-47745-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.