Gemcitabine hydrochloride

Also known as: Gemcitabine HCl, dFdC, LY188011, Gemzar, 2',2'-Difluoro-2'-deoxycytidine hydrochloride, Cytidine, 2'-deoxy-2',2'-difluoro-, hydrochloride (1:1), 2'-Deoxy-2',2'-difluorocytidine hydrochloride, 4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2(1H)-pyrimidinone hydrochloride, MFCD01735988

Gemcitabine hydrochloride (CAS 122111-03-9) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C9H12ClF2N3O4 and a molecular weight of 299.659 g/mol. Key properties include a melting point of >250°C dec. and a boiling point of 482.7ºC at 760 mmHg. It is classified under GHS with signal word Danger and hazard statements H360 — May damage fertility or the unborn child. No supplier offers are currently listed; request a quote. Record last updated Nov 3, 2026.

CAS No.: 122111-03-9
Jingsj CID: J-205-1
Molecular Formula: C₉H₁₂ClF₂N₃O₄
Molecular Weight: 299.659 g/mol
Category: Organic Acids
Last updated: 11/3/2026

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Physicochemical Properties

Melting Point	>250°C dec.
Boiling Point	482.7ºC at 760 mmHg
Exact Mass	299.048431
PSA	110.60000
LogP	0.09460
Vapor Pressure	2.41E-11mmHg at 25°C
Storage Conditions	Desiccate at +4°C

GHS Safety & Compliance

Health HazardSignal word: Danger

H360 — May damage fertility or the unborn child

Activity & Biological Data

Target	DNA synthesis[1]
Additional Information	[1]. Wang H, et al. Enhanced efficacy of Gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrativenucleoside transporter 1. Anticancer Res. 2011 Oct;31(10):3171-80 [2]. Joshi G, et al. Enhanced bioavailability and intestinal uptake of Gemcitabine HCl loaded PLGA nanoparticles after oral delivery. Eur J Pharm Sci. 2014 Aug 18;60:80-9. [3]. Reddy LH, et al. Preclinical toxicology (subacute and acute) and efficacy of a new squalenoyl Gemcitabine anticancernanomedicine. J Pharmacol Exp Ther. 2008 May;325(2):484-90.

Target

DNA synthesis[1]

Additional Information

[1]. Wang H, et al. Enhanced efficacy of Gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrativenucleoside transporter 1. Anticancer Res. 2011 Oct;31(10):3171-80 [2]. Joshi G, et al. Enhanced bioavailability and intestinal uptake of Gemcitabine HCl loaded PLGA nanoparticles after oral delivery. Eur J Pharm Sci. 2014 Aug 18;60:80-9. [3]. Reddy LH, et al. Preclinical toxicology (subacute and acute) and efficacy of a new squalenoyl Gemcitabine anticancernanomedicine. J Pharmacol Exp Ther. 2008 May;325(2):484-90.

Customs & Trade Information

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Gemcitabine hydrochloride?

The CAS number of Gemcitabine hydrochloride is 122111-03-9.

What are the molecular formula and molecular weight of Gemcitabine hydrochloride?

Gemcitabine hydrochloride has molecular formula C9H12ClF2N3O4 and molecular weight 299.659 g/mol.

Is Gemcitabine hydrochloride hazardous?

Gemcitabine hydrochloride has GHS signal word Danger and hazard statements H360 — May damage fertility or the unborn child.

What are the upstream and downstream products of Gemcitabine hydrochloride?

For Gemcitabine hydrochloride, Upstream Products: Gemcitabine, 2-Deoxy-2,2-difluoro-D-erythro-pentofuranose 3,5-dibenzoate, N4-Acetylcytosine; Downstream Products: Gemcitabine, 2',2'-Difluoro-2'-deoxyuridine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 11/3/2026

How to cite: Jingsj. "Gemcitabine hydrochloride (CAS 122111-03-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-205-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.