Rolipram

Also known as: (±)-Rolipram, (R,S)-Rolipram, ZK 62711, SB 95952, 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, 4-(3-Cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one, Roliprame, Rolipramum, Adeo

Rolipram (CAS 61413-54-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C16H21NO3 and a molecular weight of 275.343 g/mol. Key properties include a melting point of 127-133ºC, a boiling point of 472.7±45.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 239.7±28.7 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 61413-54-5
Jingsj CID: J-45386-1
Molecular Formula: C₁₆H₂₁NO₃
Molecular Weight: 275.343 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	127-133ºC
Boiling Point	472.7±45.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	239.7±28.7 °C
Exact Mass	275.152130
PSA	47.56000
LogP	1.43
Vapor Pressure	0.0±1.2 mmHg at 25°C
Refractive Index	1.552
Storage Conditions	0-6℃
Additional Property	H2O: 0.2 mg/mL

Activity & Biological Data

Target	IC50: 3 nM (PDE4A), 130 nM (PDE4B), 240 nM (PDE4D)[1]
Additional Information	[1]. MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr [2]. Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169(7):1525-36. [3]. Shalaby AM, et al. Effect of rolipram, a phosphodiesterase enzyme type-4 inhibitor, on γ-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress. J Pharmacol Pharmacother. 2012 Apr;3(2):132-7.

Target

IC50: 3 nM (PDE4A), 130 nM (PDE4B), 240 nM (PDE4D)[1]

Additional Information

[1]. MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr [2]. Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169(7):1525-36. [3]. Shalaby AM, et al. Effect of rolipram, a phosphodiesterase enzyme type-4 inhibitor, on γ-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress. J Pharmacol Pharmacother. 2012 Apr;3(2):132-7.

Customs & Trade Information

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Rolipram?

The CAS number of Rolipram is 61413-54-5.

What are the molecular formula and molecular weight of Rolipram?

Rolipram has molecular formula C16H21NO3 and molecular weight 275.343 g/mol.

What are the upstream and downstream products of Rolipram?

For Rolipram, Upstream Products: Methanol, 4-Bromo-2-(cyclopentyloxy)-1-methoxybenzene; Downstream Products: (R)-(-)-Rolipram, (S)-(+)-Rolipram.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Rolipram (CAS 61413-54-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-45386-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.