(S)-(+)-Rolipram

Also known as: (+)-Rolipram, S-(+)-Rolipram, (S)-Rolipram, Rolipram S-(+)-, (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one, (S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one

(S)-(+)-Rolipram (CAS 85416-73-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C16H21NO3 and a molecular weight of 275.343 g/mol. Key properties include a melting point of 133-136ºC, a boiling point of 472.7±45.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 239.7±28.7 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 85416-73-5
Jingsj CID: J-1955448-4
Molecular Formula: C₁₆H₂₁NO₃
Molecular Weight: 275.343 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	133-136ºC
Boiling Point	472.7±45.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	239.7±28.7 °C
Exact Mass	275.152130
PSA	47.56000
LogP	1.43
Vapor Pressure	0.0±1.2 mmHg at 25°C
Refractive Index	1.552
Storage Conditions	Store at RT

Activity & Biological Data

Additional Information	[1]. Griswold, D.E., et al., Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation, 1993. 17(3): p. 333-44. [2]. Zhu, J., E. Mix, and B. Winblad, The antidepressant and antiinflammatory effects of rolipram in the central nervous system. CNS Drug Rev, 2001. 7(4): p. 387-98. [3]. MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr [4]. Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169(7):1525-36.

Additional Information

[1]. Griswold, D.E., et al., Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation, 1993. 17(3): p. 333-44. [2]. Zhu, J., E. Mix, and B. Winblad, The antidepressant and antiinflammatory effects of rolipram in the central nervous system. CNS Drug Rev, 2001. 7(4): p. 387-98. [3]. MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr [4]. Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169(7):1525-36.

Customs & Trade Information

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of (S)-(+)-Rolipram?

The CAS number of (S)-(+)-Rolipram is 85416-73-5.

What are the molecular formula and molecular weight of (S)-(+)-Rolipram?

(S)-(+)-Rolipram has molecular formula C16H21NO3 and molecular weight 275.343 g/mol.

What are the upstream and downstream products of (S)-(+)-Rolipram?

For (S)-(+)-Rolipram, Upstream Products: Cyclopentyl bromide, 3-(Cyclopentyloxy)-4-methoxybenzaldehyde, Isovanillin.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "(S)-(+)-Rolipram (CAS 85416-73-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1955448-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.