Tretinoin

Also known as: all-trans-Retinoic acid, Retinoic acid, Vitamin A acid, all-trans-Tretinoin, ATRA, all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid, (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid, abarel, aknoten, effederm, eudyna, retin-a, Retinoic acid, all-trans-, trans-Retinoic acid, trans-Vitamin A acid

Tretinoin (CAS 302-79-4) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C20H28O2 and a molecular weight of 300.435 g/mol. Key properties include a melting point of 179-184ºC, a boiling point of 462.8±14.0 °C at 760 mmHg, a density of 1.0±0.1 g/cm3 and a flash point of 350.6±11.0 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 302-79-4
Jingsj CID: J-43567-6
Molecular Formula: C₂₀H₂₈O₂
Molecular Weight: 300.435 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	179-184ºC
Boiling Point	462.8±14.0 °C at 760 mmHg
Density	1.0±0.1 g/cm3
Flash Point	350.6±11.0 °C
Exact Mass	300.208923
PSA	37.30000
LogP	6.83
Vapor Pressure	0.0±2.5 mmHg at 25°C
Refractive Index	1.556
Storage Conditions	2-8°C
Stability	Store Dry in Freezer at -20°C for up to 1 year; in Solution at -20°C for up to 3 Months.
Additional Property	insoluble

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed

Activity & Biological Data

Target	PPARβ/δ:17 nM (Kd) PPARα:103 nM (Kd) PPARγ:178 nM (Kd) RARα:14 nM (IC50) RARβ:14 nM (IC50) RARγ:14 nM (IC50) Human Endogenous Metabolite
Additional Information	[1]. Wu L, et al. Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis. PLoS One. 2016 Apr 14;11(4):e0153556. [2]. Shaw N, et al. Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor beta/delta. J Biol Chem. 2003 Oct 24;278(43):41589-92. [3]. Yu S, et al. Retinoic acid induces neurogenesis by activating both retinoic acid receptors (RARs) and peroxisomeproliferator-activated receptor β/δ (PPARβ/δ). J Biol Chem. 2012 Dec 7;287(50):42195-205. [4]. Kam RK, et al. Retinoic acid synthesis and functions in early embryonic development. Cell Biosci. 2012 Mar 22;2(1):11. [5]. Apfel C, et al. A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7129-33.

Target

PPARβ/δ:17 nM (Kd) PPARα:103 nM (Kd) PPARγ:178 nM (Kd) RARα:14 nM (IC50) RARβ:14 nM (IC50) RARγ:14 nM (IC50) Human Endogenous Metabolite

Additional Information

[1]. Wu L, et al. Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis. PLoS One. 2016 Apr 14;11(4):e0153556. [2]. Shaw N, et al. Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor beta/delta. J Biol Chem. 2003 Oct 24;278(43):41589-92. [3]. Yu S, et al. Retinoic acid induces neurogenesis by activating both retinoic acid receptors (RARs) and peroxisomeproliferator-activated receptor β/δ (PPARβ/δ). J Biol Chem. 2012 Dec 7;287(50):42195-205. [4]. Kam RK, et al. Retinoic acid synthesis and functions in early embryonic development. Cell Biosci. 2012 Mar 22;2(1):11. [5]. Apfel C, et al. A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7129-33.

Customs & Trade Information

HS Code	2916209090
Summary	2916209090 other cyclanic, cyclenic or cyclotherpenic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Tretinoin?

The CAS number of Tretinoin is 302-79-4.

What are the molecular formula and molecular weight of Tretinoin?

Tretinoin has molecular formula C20H28O2 and molecular weight 300.435 g/mol.

Is Tretinoin hazardous?

Tretinoin has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.

What are the upstream and downstream products of Tretinoin?

For Tretinoin, Upstream Products: Retinol, all-trans-Retinal, beta-ionone; Downstream Products: Isotretinoin, Tretinoin, all-trans-4-Oxoretinoic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Tretinoin (CAS 302-79-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-43567-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.