Isoliquiritigenin

Also known as: 2',4,4'-Trihydroxychalcone, 4,2',4'-Trihydroxychalcone, (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, GU17, ISL, 4,2μ,4μ-Trihydroxychalcone, Isoliquiritigenin (RG), Isoliquiritigenin (P), Isqliquiritigenin, iso-Liquiritigenin, MFCD00075907

Isoliquiritigenin (CAS 961-29-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C15H12O4 and a molecular weight of 256.253 g/mol. Key properties include a melting point of 206-210°C, a boiling point of 504.0±42.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 272.7±24.4 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 961-29-5
Jingsj CID: J-35574-8
Molecular Formula: C₁₅H₁₂O₄
Molecular Weight: 256.253 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	206-210°C
Boiling Point	504.0±42.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	272.7±24.4 °C
Exact Mass	256.073547
PSA	77.76000
LogP	3.11
Vapor Pressure	0.0±1.3 mmHg at 25°C
Refractive Index	1.715
Additional Property	H2O: <0.1 mg/mL

Activity & Biological Data

Target	IC50: 320 nM (Aldose reductase)
Additional Information	[1]. Aida K, et al. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56(3):254-8. [2]. Sato Y, et al. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol Pharm Bull. 2007 Jan;30(1):145-9. [3]. Zhang X. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm. 2013;2013:390890. [4]. Chen X, et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl). 2012 Nov;90(11):1311-9.

Target

IC50: 320 nM (Aldose reductase)

Additional Information

[1]. Aida K, et al. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56(3):254-8. [2]. Sato Y, et al. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol Pharm Bull. 2007 Jan;30(1):145-9. [3]. Zhang X. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm. 2013;2013:390890. [4]. Chen X, et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl). 2012 Nov;90(11):1311-9.

Customs & Trade Information

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Isoliquiritigenin?

The CAS number of Isoliquiritigenin is 961-29-5.

What are the molecular formula and molecular weight of Isoliquiritigenin?

Isoliquiritigenin has molecular formula C15H12O4 and molecular weight 256.253 g/mol.

What are the upstream and downstream products of Isoliquiritigenin?

For Isoliquiritigenin, Upstream Products: 2,4-Dihydroxyacetophenone, 4-Hydroxybenzaldehyde, 4-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde; Downstream Products: Liquiritigenin, 2,4-Dihydroxybenzoic acid, 3,7,4'-Trihydroxyflavone.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Isoliquiritigenin (CAS 961-29-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-35574-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.