Liquiritigenin

Also known as: (2S)-7-Hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one, 4',7-Dihydroxyflavanone, (S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, 7-Hydroxy-2-(4-hydroxyphenyl)chroman-4-one

Liquiritigenin (CAS 578-86-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C15H12O4 and a molecular weight of 256.253 g/mol. Key properties include a melting point of 206-208ºC, a boiling point of 529.5±50.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 206.9±23.6 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 578-86-9
Jingsj CID: J-1344715-9
Molecular Formula: C₁₅H₁₂O₄
Molecular Weight: 256.253 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	206-208ºC
Boiling Point	529.5±50.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	206.9±23.6 °C
Exact Mass	256.073547
PSA	66.76000
LogP	2.76
Vapor Pressure	0.0±1.4 mmHg at 25°C
Refractive Index	1.662

Activity & Biological Data

Target	EC50: 36.5 nM (activation of the ERE tk-Luc)[1]
Additional Information	[1]. Mersereau JE, et al. Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol Cell Endocrinol. 2008 Feb 13;283(1-2):49-57. [2]. Suh KS, et al. Protective effect of liquiritigenin against methylglyoxal cytotoxicity in osteoblastic MC3T3-E1 cells. Food Funct. 2014 Jul 25;5(7):1432-40. [3]. Tao W, et al. Liquiritigenin reverses depression-like behavior in unpredictable chronic mild stress-induced mice by regulating PI3K/Akt/mTOR mediated BDNF/TrkB pathway. Behav Brain Res. 2016 Jul 15;308:177-86.

Target

EC50: 36.5 nM (activation of the ERE tk-Luc)[1]

Additional Information

[1]. Mersereau JE, et al. Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol Cell Endocrinol. 2008 Feb 13;283(1-2):49-57. [2]. Suh KS, et al. Protective effect of liquiritigenin against methylglyoxal cytotoxicity in osteoblastic MC3T3-E1 cells. Food Funct. 2014 Jul 25;5(7):1432-40. [3]. Tao W, et al. Liquiritigenin reverses depression-like behavior in unpredictable chronic mild stress-induced mice by regulating PI3K/Akt/mTOR mediated BDNF/TrkB pathway. Behav Brain Res. 2016 Jul 15;308:177-86.

Frequently Asked Questions

What is the CAS number of Liquiritigenin?

The CAS number of Liquiritigenin is 578-86-9.

What are the molecular formula and molecular weight of Liquiritigenin?

Liquiritigenin has molecular formula C15H12O4 and molecular weight 256.253 g/mol.

What are the upstream and downstream products of Liquiritigenin?

For Liquiritigenin, Upstream Products: Isoliquiritigenin, Liquiritin; Downstream Products: Isobavachin, 4-Hydroxycinnamic acid, Resorcinol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Liquiritigenin (CAS 578-86-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1344715-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.