Podophyllotoxin
Also known as: Podofilox, Condyline, Condylox, Wartec, Warticon, Podophyllinic acid lactone, (5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, (5R,5aR,8aR,9R)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one, (5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one, 1-Hydroxy-2-hydroxymethyl-6,7-methylenedioxy-4-(3',4',5'-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-3-carboxylic Acid Lactone, MFCD00075290, EINECS 208-250-4
Podophyllotoxin (CAS 518-28-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H22O8 and a molecular weight of 414.405 g/mol. Key properties include a melting point of 183-184 °C(lit.), a boiling point of 597.9±50.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 210.2±23.6 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed, H310 and H315 — Causes skin irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 518-28-5
- Jingsj CID
- J-35359-3
- Molecular Formula
- C22H22O8
- Molecular Weight
- 414.405 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 183-184 °C(lit.) |
|---|---|
| Boiling Point | 597.9±50.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 210.2±23.6 °C |
| Exact Mass | 414.131470 |
| PSA | 92.68000 |
| LogP | 1.60 |
| Vapor Pressure | 0.0±1.8 mmHg at 25°C |
| Refractive Index | 1.606 |
GHS Safety & Compliance
- H301 — Toxic if swallowed
- H310
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Additional Information | [1]. Wang B, Chen L, Zhen H, et al. Proteomic changes induced by podophyllotoxin in human cervical carcinoma HeLa cells. Am J Chin Med. 2013;41(1):163-75. [2]. Guerrero E, Abad A, Montenegro G, et al. Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. Pharm Biol. 2013 Jan 31. [3]. Li M, Zhou L, Yang D, et al. Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome. BMC Complement Altern Med. 2012 Dec 22;12:263. [4]. Prasad V, Chaudhuri AR, Curcio M, et al. Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay. J Protein Chem. 1998 Oct;17(7):663-8. [5]. Podophyllotoxin |
|---|
Customs & Trade Information
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Podophyllotoxin?
The CAS number of Podophyllotoxin is 518-28-5.
What are the molecular formula and molecular weight of Podophyllotoxin?
Podophyllotoxin has molecular formula C22H22O8 and molecular weight 414.405 g/mol.
Is Podophyllotoxin hazardous?
Podophyllotoxin has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H310; H315 — Causes skin irritation.
What are the upstream and downstream products of Podophyllotoxin?
For Podophyllotoxin, Downstream Products: 4'-Demethylpodophyllotoxin, Picropodophyllotoxin, 4'-Demethylepipodophyllotoxin.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Podophyllotoxin (CAS 518-28-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-35359-3 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.