Picropodophyllotoxin
Also known as: Picropodophyllin, AXL1717, PPP, (-)PPP, (5R,5aS,8aR,9R)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one, NSC 36407, IGF-1R Inhibitor, Picropodophyllinic Acid Lactone
Picropodophyllotoxin (CAS 477-47-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H22O8 and a molecular weight of 414.405 g/mol. Key properties include a melting point of 225-227ºC, a boiling point of 597.9±50.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 210.2±23.6 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed, H312 — Harmful in contact with skin and H315 — Causes skin irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 477-47-4
- Jingsj CID
- J-1977475-5
- Molecular Formula
- C22H22O8
- Molecular Weight
- 414.405 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 225-227ºC |
|---|---|
| Boiling Point | 597.9±50.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 210.2±23.6 °C |
| Exact Mass | 414.131470 |
| PSA | 92.68000 |
| LogP | 1.60 |
| Vapor Pressure | 0.0±1.8 mmHg at 25°C |
| Refractive Index | 1.606 |
| Storage Conditions | 2-8°C |
GHS Safety & Compliance
- H301 — Toxic if swallowed
- H312 — Harmful in contact with skin
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Target | IC50: 1 nM (IGF-1R) |
|---|---|
| Additional Information | [1]. Girnita A, et al. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res. 2004 Jan 1;64(1):236-42. [2]. Menu E, et al. Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model. Blood. 2006 Jan 15;107(2):655-60. Epub 2005 Jul 26. [3]. Bieghs L, et al. The IGF-1 receptor inhibitor picropodophyllin potentiates the anti-myeloma activity of a BH3-mimetic. Oncotarget. 2014 Nov 30;5(22):11193-208. [4]. Tomizawa M, et al. Picropodophyllin and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells. Oncol Lett. 2014 Nov;8(5):2023-2026. Epub 2014 Aug 27. [5]. Stromberg T, et al. IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells. Blood. 2006 Jan 15;107(2):669-78. Epub 2005 Sep 15. [6]. Kong YL, et al. Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway. Acta Pharmacol Sin. 2016 Feb;37(2):217-27. |
Frequently Asked Questions
What is the CAS number of Picropodophyllotoxin?
The CAS number of Picropodophyllotoxin is 477-47-4.
What are the molecular formula and molecular weight of Picropodophyllotoxin?
Picropodophyllotoxin has molecular formula C22H22O8 and molecular weight 414.405 g/mol.
Is Picropodophyllotoxin hazardous?
Picropodophyllotoxin has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H312 — Harmful in contact with skin; H315 — Causes skin irritation.
What are the upstream and downstream products of Picropodophyllotoxin?
For Picropodophyllotoxin, Upstream Products: Podophyllotoxin; Downstream Products: Etoposide, Podophyllotoxin.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Picropodophyllotoxin (CAS 477-47-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1977475-5 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.