4'-Demethylpodophyllotoxin

Also known as: 4'-O-demethylpodophyllotoxin, 4-demethylepipodophyllotoxin, 9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5ah)-one, (5R,5aR,8aR,9R)-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one, Etoposide EP Impurity L, Etoposide Impurity 12

4'-Demethylpodophyllotoxin (CAS 40505-27-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C21H20O8 and a molecular weight of 400.37900 g/mol. Key properties include a boiling point of 626.5ºC at 760 mmHg, a density of 1.446 g/cm3 and a flash point of 224.4ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 40505-27-9
Jingsj CID: J-1398355-6
Molecular Formula: C₂₁H₂₀O₈
Molecular Weight: 400.37900 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	626.5ºC at 760 mmHg
Density	1.446 g/cm3
Flash Point	224.4ºC
Exact Mass	400.11600
PSA	103.68000
LogP	2.10620
Refractive Index	1.637
Storage Conditions	-20℃

Activity & Biological Data

Additional Information	[1]. David E.Jackson, et al. Aryltetralin lignans from Podophyllum hexandrum and Podophyllum peltatum. Phytochemistry, 1984, 23(5): 1147-1152. [2]. Zilla MK, et al. 4'-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells. Chem Biol Interact. 2014 Dec 5;224:100-7.

Frequently Asked Questions

What is the CAS number of 4'-Demethylpodophyllotoxin?

The CAS number of 4'-Demethylpodophyllotoxin is 40505-27-9.

What are the molecular formula and molecular weight of 4'-Demethylpodophyllotoxin?

4'-Demethylpodophyllotoxin has molecular formula C21H20O8 and molecular weight 400.37900 g/mol.

What are the upstream and downstream products of 4'-Demethylpodophyllotoxin?

For 4'-Demethylpodophyllotoxin, Upstream Products: Podophyllotoxin; Downstream Products: Picropodophyllotoxin, Podophyllotoxin, 4'-Demethyldeoxypodophyllotoxin.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "4'-Demethylpodophyllotoxin (CAS 40505-27-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1398355-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.