Naproxen sodium

Also known as: Anaprox, Aleve, (S)-Naproxen sodium salt, Sodium (S)-2-(6-methoxynaphthalen-2-yl)propanoate, Naprelan, RS-3650

Naproxen sodium (CAS 26159-34-2) is a compound in the Aromatic Hydrocarbons category listed in the Jingsj chemical database. It has the molecular formula C14H13NaO3 and a molecular weight of 252.241 g/mol. Key properties include a melting point of 250-251ºC, a boiling point of 403.9ºC at 760 mmHg and a flash point of 154.5ºC. It is classified under GHS with signal word Danger and hazard statements H302 — Harmful if swallowed and H360 — May damage fertility or the unborn child. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 26159-34-2
Jingsj CID: J-32768-6
Molecular Formula: C₁₄H₁₃NaO₃
Molecular Weight: 252.241 g/mol
Category: Aromatic Hydrocarbons
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	250-251ºC
Boiling Point	403.9ºC at 760 mmHg
Flash Point	154.5ºC
Exact Mass	252.076233
PSA	49.36000
LogP	1.70180
Vapor Pressure	3.01E-07mmHg at 25°C
Storage Conditions	Desiccate at RT

GHS Safety & Compliance

Irritant / Health HazardSignal word: Danger

H302 — Harmful if swallowed
H360 — May damage fertility or the unborn child

Activity & Biological Data

Target	COX-2:5.65 μM (IC50, in intact cells ) COX-1:9.55 μM (IC50, in intact cells )
Additional Information	[1]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. [2]. Rosa AC, et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351(2):308-16. [3]. Krekels EH, et al. Pharmacokinetic-pharmacodynamic modeling of the inhibitory effects of naproxen on the time-courses of inflammatory pain, fever, and the ex vivo synthesis of TXB2 and PGE2 in rats.

Target

COX-2:5.65 μM (IC50, in intact cells ) COX-1:9.55 μM (IC50, in intact cells )

Additional Information

[1]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. [2]. Rosa AC, et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351(2):308-16. [3]. Krekels EH, et al. Pharmacokinetic-pharmacodynamic modeling of the inhibitory effects of naproxen on the time-courses of inflammatory pain, fever, and the ex vivo synthesis of TXB2 and PGE2 in rats.

Customs & Trade Information

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Naproxen sodium?

The CAS number of Naproxen sodium is 26159-34-2.

What are the molecular formula and molecular weight of Naproxen sodium?

Naproxen sodium has molecular formula C14H13NaO3 and molecular weight 252.241 g/mol.

Is Naproxen sodium hazardous?

Naproxen sodium has GHS signal word Danger and hazard statements H302 — Harmful if swallowed; H360 — May damage fertility or the unborn child.

What are the upstream and downstream products of Naproxen sodium?

For Naproxen sodium, Upstream Products: Naproxen, (±)-2-(6-Methoxy-2-naphthyl)propionic acid; Downstream Products: Naproxcinod.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Naproxen sodium (CAS 26159-34-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-32768-6 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.