1-[(4-Chlorophenyl)(phenyl)methyl]piperazine

Also known as: 1-(4-Chlorobenzhydryl)piperazine, 1-(4-Chloro-α-phenylbenzyl)piperazine, 1-(p-Chlorobenzhydryl)piperazine, Norchlorcyclizine, N-(4-Chlorobenzhydryl)piperazine, NSC 86164, UNII:T875VN0D6E, 4-(4-Chlorobenzhydryl)piperazine

1-[(4-Chlorophenyl)(phenyl)methyl]piperazine (CAS 303-26-4) is a compound in the Aromatic Hydrocarbons category listed in the Jingsj chemical database. It has the molecular formula C17H19ClN2 and a molecular weight of 286.80 g/mol. Key properties include a melting point of 65-70 °C(lit.), a boiling point of 409.1±0.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 193.3±26.5 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 303-26-4
Jingsj CID: J-30522-6
Molecular Formula: C₁₇H₁₉ClN₂
Molecular Weight: 286.80 g/mol
Category: Aromatic Hydrocarbons
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	65-70 °C(lit.)
Boiling Point	409.1±0.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	193.3±26.5 °C
Exact Mass	286.123688
PSA	15.27000
LogP	3.44
Vapor Pressure	0.0±0.9 mmHg at 25°C
Refractive Index	1.592
Storage Conditions	Refrigerator

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Additional Information	[1]. Gaertner, HJ, Breyer, U., and Liomin, G.Chronic administration of chlorcyclizine and meclizine to rats: Accumulation of a metabolite formed by piperazine ring cleavage J. Pharmacol. Exp. Ther.185(2)195-201(1973) [2]. Kuntzman, R., Klutch, A., Tsai, I., et al.Physiological distribution and metabolic inactivation of chlorcyclizine and cyclizineJ. Pharmacol. Exp. Ther.149(1)29-35(1965) [3]. Simpson, D., Skellern, GG, and Miller, JHMethod for the control of known impurities in hydroxyzine hydrochlorideJ. Pharm . Biomed. Anal.14(8-10)1371-1375(1996) [4]. Javid, FS, Shafaat, A., and Zarghi, A. Determination of cetirizine and its impurities in bulk and tablet formulation using a validated capillary zone electrophoretic methodJ. Anal. Chem.69(5)442-447(2014) [5]. Back, SK, Kam, YL, Oh, JA, et al.Synthesis and evaluation of (4-chlorobenzhydryl) piperazine amides as sodium channel Nav7 inhibitorsBull. Korean Chem. Soc.36(9)2290-2297(2015) [6]. Yarim, M., Koksal, M., Durmaz, I., et al.Cancer cell cytotoxicities of 1-(4-substitutedbenzoyl)-4 -(4-chlorobenzhydryl)piperazine derivativesInt. J. Mol. Sci.13(7)8071-8085(2012) [7]. Narsaiah, AV, and Narssimha, P.Efficient synthesis of antihistamines clocinizine and chlorcyclizineMed. Chem. Res.21538- 541 (2012)

Additional Information

[1]. Gaertner, HJ, Breyer, U., and Liomin, G.Chronic administration of chlorcyclizine and meclizine to rats: Accumulation of a metabolite formed by piperazine ring cleavage J. Pharmacol. Exp. Ther.185(2)195-201(1973) [2]. Kuntzman, R., Klutch, A., Tsai, I., et al.Physiological distribution and metabolic inactivation of chlorcyclizine and cyclizineJ. Pharmacol. Exp. Ther.149(1)29-35(1965) [3]. Simpson, D., Skellern, GG, and Miller, JHMethod for the control of known impurities in hydroxyzine hydrochlorideJ. Pharm . Biomed. Anal.14(8-10)1371-1375(1996) [4]. Javid, FS, Shafaat, A., and Zarghi, A. Determination of cetirizine and its impurities in bulk and tablet formulation using a validated capillary zone electrophoretic methodJ. Anal. Chem.69(5)442-447(2014) [5]. Back, SK, Kam, YL, Oh, JA, et al.Synthesis and evaluation of (4-chlorobenzhydryl) piperazine amides as sodium channel Nav7 inhibitorsBull. Korean Chem. Soc.36(9)2290-2297(2015) [6]. Yarim, M., Koksal, M., Durmaz, I., et al.Cancer cell cytotoxicities of 1-(4-substitutedbenzoyl)-4 -(4-chlorobenzhydryl)piperazine derivativesInt. J. Mol. Sci.13(7)8071-8085(2012) [7]. Narsaiah, AV, and Narssimha, P.Efficient synthesis of antihistamines clocinizine and chlorcyclizineMed. Chem. Res.21538- 541 (2012)

Customs & Trade Information

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of 1-[(4-Chlorophenyl)(phenyl)methyl]piperazine?

The CAS number of 1-[(4-Chlorophenyl)(phenyl)methyl]piperazine is 303-26-4.

What are the molecular formula and molecular weight of 1-[(4-Chlorophenyl)(phenyl)methyl]piperazine?

1-[(4-Chlorophenyl)(phenyl)methyl]piperazine has molecular formula C17H19ClN2 and molecular weight 286.80 g/mol.

Is 1-[(4-Chlorophenyl)(phenyl)methyl]piperazine hazardous?

1-[(4-Chlorophenyl)(phenyl)methyl]piperazine has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.

What are the upstream and downstream products of 1-[(4-Chlorophenyl)(phenyl)methyl]piperazine?

For 1-[(4-Chlorophenyl)(phenyl)methyl]piperazine, Upstream Products: Piperazine, 4-Chlorobenzhydryl chloride, 4-Chlorobenzhydrol; Downstream Products: (S)-(+)-1-[(4-Chlorophenyl)phenylmethyl]piperazine, Clocinizine, Chlorcyclizine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "1-[(4-Chlorophenyl)(phenyl)methyl]piperazine (CAS 303-26-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-30522-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.