Hydroxyzine dihydrochloride
Also known as: 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride, Hydroxyzine hydrochloride, Hydroxyzine 2HCl, Alamon, Atarax dihydrochloride, Ataraxoid dihydrochloride, Aterax dihydrochloride, Durrax, Neurolax, Orgatrax, Quies, Tran-Q dihydrochloride, Vistaril steraject
Hydroxyzine dihydrochloride (CAS 2192-20-3) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C21H29Cl3N2O2 and a molecular weight of 447.826 g/mol. Key properties include a melting point of 190-192°C, a boiling point of 499.2ºC at 760 mmHg, a density of 1.182 g/cm3 and a flash point of 255.7ºC. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed, H315 — Causes skin irritation and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 2192-20-3
- Jingsj CID
- J-25023-7
- Molecular Formula
- C21H29Cl3N2O2
- Molecular Weight
- 447.826 g/mol
- Category
- Organic Acids
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 190-192°C |
|---|---|
| Boiling Point | 499.2ºC at 760 mmHg |
| Density | 1.182 g/cm3 |
| Flash Point | 255.7ºC |
| Exact Mass | 446.129456 |
| PSA | 35.94000 |
| LogP | 4.53570 |
| Vapor Pressure | 8.78E-11mmHg at 25°C |
| Additional Property | H2O: soluble |
GHS Safety & Compliance
- H302 — Harmful if swallowed
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Additional Information | [1]. Minogiannis, P., et al., Hydroxyzine inhibits neurogenic bladder mast cell activation. Int J Immunopharmacol, 1998. 20(10): p. 553-63. [2]. Dimitriadou, V., X. Pang, and T.C. Theoharides, Hydroxyzine inhibits experimental allergic encephalomyelitis (EAE) and associated brain mast cell activation. Int J Immunopharmacol, 2000. 22(9): p. 673-84. [3]. Kan, W.M., et al., Effect of hydroxyzine on the transport of etoposide in rat small intestine. Anticancer Drugs, 2001. 12(3): p. 267-73. [4]. Morichi, R. and G. Pepeu, A study of the influence of hydroxyzine and diazepam on morphine antinociceptoion in the rat. Pain, 1979. 7(2): p. 173-80. |
|---|
Customs & Trade Information
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Hydroxyzine dihydrochloride?
The CAS number of Hydroxyzine dihydrochloride is 2192-20-3.
What are the molecular formula and molecular weight of Hydroxyzine dihydrochloride?
Hydroxyzine dihydrochloride has molecular formula C21H29Cl3N2O2 and molecular weight 447.826 g/mol.
Is Hydroxyzine dihydrochloride hazardous?
Hydroxyzine dihydrochloride has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H315 — Causes skin irritation; H319 — Causes serious eye irritation.
What are the upstream and downstream products of Hydroxyzine dihydrochloride?
For Hydroxyzine dihydrochloride, Upstream Products: 1-[(4-Chlorophenyl)(phenyl)methyl]piperazine, 2-(2-Chloroethoxy)ethanol.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Hydroxyzine dihydrochloride (CAS 2192-20-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-25023-7 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.