Hydrocortisone

Also known as: Cortisol, 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, Kendall's compound F, 11β,17,21-Trihydroxypregn-4-ene-3,20-dione, Hydrocortisone (USP), Hydrocorticosterone, Hydroxycortisone, Prednisolone EP Impurity A, Prednisolone Impurity 1, MFCD00011654, Compound F, Cortanal, Hycort, Hydrocort

Hydrocortisone (CAS 50-23-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C21H30O5 and a molecular weight of 362.460 g/mol. Key properties include a melting point of 211-214 °C(lit.), a boiling point of 566.5±50.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 310.4±26.6 °C. It is classified under GHS with signal word Warning and hazard statements H361 — Suspected of damaging fertility or the unborn child. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 50-23-7
Jingsj CID: J-29842-0
Molecular Formula: C₂₁H₃₀O₅
Molecular Weight: 362.460 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	211-214 °C(lit.)
Boiling Point	566.5±50.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	310.4±26.6 °C
Exact Mass	362.209320
PSA	94.83000
LogP	1.43
Vapor Pressure	0.0±3.5 mmHg at 25°C
Refractive Index	1.595

GHS Safety & Compliance

Health HazardSignal word: Warning

H361 — Suspected of damaging fertility or the unborn child

Activity & Biological Data

Target	Human Endogenous Metabolite
Additional Information	[1]. F?rster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586(7):1937-49. [2]. Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108(2):242-9. [3]. Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107(5):776-84.

Target

Human Endogenous Metabolite

Additional Information

[1]. F?rster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586(7):1937-49. [2]. Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108(2):242-9. [3]. Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107(5):776-84.

Customs & Trade Information

HS Code	2937210000

Frequently Asked Questions

What is the CAS number of Hydrocortisone?

The CAS number of Hydrocortisone is 50-23-7.

What are the molecular formula and molecular weight of Hydrocortisone?

Hydrocortisone has molecular formula C21H30O5 and molecular weight 362.460 g/mol.

Is Hydrocortisone hazardous?

Hydrocortisone has GHS signal word Warning and hazard statements H361 — Suspected of damaging fertility or the unborn child.

What are the upstream and downstream products of Hydrocortisone?

For Hydrocortisone, Upstream Products: Hydrocortisone acetate, Cortisone, Cortisone acetate; Downstream Products: Adrenosterone, 11β-Hydroxyandrost-4-ene-3,17-dione, 11β-Hydroxytestosterone.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Hydrocortisone (CAS 50-23-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-29842-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.