Lapatinib
Also known as: GW572016, Tykerb, Tyverb, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine, N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]quinazolin-4-amine, N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine, 4-{[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]amino}-6-(5-{[(2-methanesulphonyl-ethyl)amino]methyl}-furan-2-yl)quinazoline, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine, Lapatinib [INN], GW-2016
Lapatinib (CAS 231277-92-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C29H26ClFN4O4S and a molecular weight of 581.057 g/mol. Key properties include a melting point of 147 °C, a boiling point of 750.7±60.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 407.8±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 231277-92-2
- Jingsj CID
- J-29700-7
- Molecular Formula
- C29H26ClFN4O4S
- Molecular Weight
- 581.057 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 147 °C |
|---|---|
| Boiling Point | 750.7±60.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 407.8±32.9 °C |
| Exact Mass | 580.134705 |
| PSA | 114.73000 |
| LogP | 5.14 |
| Vapor Pressure | 0.0±2.5 mmHg at 25°C |
| Refractive Index | 1.645 |
Activity & Biological Data
| Target | EGFR:10.2 nM (IC50, Cell Free Assay) ErbB2:9.8 nM (IC50, Cell Free Assay) |
|---|---|
| Additional Information | [1]. Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1(2):85-94 [2]. O'Neill F, et al. Gene expression changes as markers of early lapatinib response in a panel of breast cancer cell lines. Mol Cancer. 2012 Jun 18;11(1):41. [3]. Eryilmaz U, et al. S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers. PLoS One. 2015 Dec 18;10(12):e0145418. [4]. Ni J, et al. Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases. Nat Med. 2016 Jul;22(7):723-6. [5]. Oncogene. 2016 Jun 9;35(23):2961-70. doi: 10.1038/onc.2015.377. Epub 2015 Dec 7. |
Customs & Trade Information
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Lapatinib?
The CAS number of Lapatinib is 231277-92-2.
What are the molecular formula and molecular weight of Lapatinib?
Lapatinib has molecular formula C29H26ClFN4O4S and molecular weight 581.057 g/mol.
What are the upstream and downstream products of Lapatinib?
For Lapatinib, Upstream Products: 2-Aminoethyl methyl sulfone, 5-[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]quinazolin-6-yl]furan-2-carbaldehyde, Lapatinib ditosylate monohydrate; Downstream Products: Lapatinib ditosylate monohydrate.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Lapatinib (CAS 231277-92-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-29700-7 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.