Lapatinib ditosylate monohydrate

Also known as: Lapatinib ditosylate, Lapatinib ditosylate hydrate, GW572016 ditosylate monohydrate, N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine bis(4-methylbenzenesulfonate) monohydrate, N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine, 4-methylbenzenesulfonate, hydrate (1:2:1), Lapatinib Ditosylate (GW-572016), Tykerb, GW572016

Lapatinib ditosylate monohydrate (CAS 388082-78-8) is a compound in the Solvents category listed in the Jingsj chemical database. It has the molecular formula C43H44ClFN4O11S3 and a molecular weight of 943.476 g/mol. Key properties include a melting point of 237 - 239 °C, a boiling point of 750.7ºC at 760 mmHg, a density of 1.403 g/mL (20.84 °C) and a flash point of 20.0 °C. No supplier offers are currently listed; request a quote. Record last updated Nov 2, 2026.

CAS No.: 388082-78-8
Jingsj CID: J-1971796-5
Molecular Formula: C₄₃H₄₄ClFN₄O₁₁S₃
Molecular Weight: 943.476 g/mol
Category: Solvents
Last updated: 11/2/2026

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Physicochemical Properties

Melting Point	237 - 239 °C
Boiling Point	750.7ºC at 760 mmHg
Density	1.403 g/mL (20.84 °C)
Flash Point	20.0 °C
Exact Mass	942.184143
PSA	249.46000
LogP	12.26450
Refractive Index	n20/D 1.5520(lit.)

Activity & Biological Data

Target	EGFR:10.8 nM (IC50) ErbB2:9.2 nM (IC50)
Additional Information	[1]. Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1(2):85-94.

Frequently Asked Questions

What is the CAS number of Lapatinib ditosylate monohydrate?

The CAS number of Lapatinib ditosylate monohydrate is 388082-78-8.

What are the molecular formula and molecular weight of Lapatinib ditosylate monohydrate?

Lapatinib ditosylate monohydrate has molecular formula C43H44ClFN4O11S3 and molecular weight 943.476 g/mol.

What are the upstream and downstream products of Lapatinib ditosylate monohydrate?

For Lapatinib ditosylate monohydrate, Upstream Products: p-Toluenesulfonic acid, 2-Aminoethylmethylsulfone hydrochloride, 5-[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]quinazolin-6-yl]furan-2-carbaldehyde; Downstream Products: Lapatinib.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 11/2/2026

How to cite: Jingsj. "Lapatinib ditosylate monohydrate (CAS 388082-78-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1971796-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.