2-Hydroxyestradiol

Also known as: 2-Hydroxy-17β-estradiol, Estra-1,3,5(10)-triene-2,3,17-triol, 2,3,17β-Trihydroxyestra-1,3,5(10)-triene, 2-Oh-estradiol, 2-Hydroxy-17-estradiol, 2-Hydroxy-17b-estradiol, 2-Hydroxyestradiol-17β

2-Hydroxyestradiol (CAS 362-05-0) is a compound in the Alcohols category listed in the Jingsj chemical database. It has the molecular formula C18H24O3 and a molecular weight of 288.38 g/mol. Key properties include a melting point of 96-104°C, a boiling point of 481.5±45.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 227.6±23.3 °C. It is classified under GHS with signal word Warning and hazard statements H351 — Suspected of causing cancer. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 362-05-0
Jingsj CID: J-22780-5
Molecular Formula: C₁₈H₂₄O₃
Molecular Weight: 288.38 g/mol
Category: Alcohols
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	96-104°C
Boiling Point	481.5±45.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	227.6±23.3 °C
Exact Mass	288.172546
PSA	60.69000
LogP	3.53
Vapor Pressure	0.0±1.3 mmHg at 25°C
Refractive Index	1.622

GHS Safety & Compliance

Health HazardSignal word: Warning

H351 — Suspected of causing cancer

Activity & Biological Data

Additional Information	[1]. C H Van Aswegen, et al. Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. J Steroid Biochem. 1989 Apr;32(4):485-92. [2]. S P Tofovic, et al. 2-Hydroxyestradiol attenuates the development of obesity, the metabolic syndrome, and vascular and renal dysfunction in obese ZSF1 rats. J Pharmacol Exp Ther. 2001 Dec;299(3):973-7. [3]. Yeon-Jin Hurh, et al. 2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells. J Toxicol Environ Health A. 2004 Dec;67(23-24):1939-53.

Additional Information

[1]. C H Van Aswegen, et al. Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. J Steroid Biochem. 1989 Apr;32(4):485-92. [2]. S P Tofovic, et al. 2-Hydroxyestradiol attenuates the development of obesity, the metabolic syndrome, and vascular and renal dysfunction in obese ZSF1 rats. J Pharmacol Exp Ther. 2001 Dec;299(3):973-7. [3]. Yeon-Jin Hurh, et al. 2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells. J Toxicol Environ Health A. 2004 Dec;67(23-24):1939-53.

Frequently Asked Questions

What is the CAS number of 2-Hydroxyestradiol?

The CAS number of 2-Hydroxyestradiol is 362-05-0.

What are the molecular formula and molecular weight of 2-Hydroxyestradiol?

2-Hydroxyestradiol has molecular formula C18H24O3 and molecular weight 288.38 g/mol.

Is 2-Hydroxyestradiol hazardous?

2-Hydroxyestradiol has GHS signal word Warning and hazard statements H351 — Suspected of causing cancer.

What are the upstream and downstream products of 2-Hydroxyestradiol?

For 2-Hydroxyestradiol, Upstream Products: 2-Methoxyestradiol, Estradiol, 2,4-Dibromoestradiol; Downstream Products: 2-Hydroxyestrone, 2-Methoxyestradiol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "2-Hydroxyestradiol (CAS 362-05-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-22780-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.