Aliskiren hemifumarate

Also known as: CGP 60536, CGP60536B, Rasilez, SPP 100, Tekturna, (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide hemifumarate, (2S,4S,5S,7S)-5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide (2E)-2-butenedioate (2:1), Aliskiren fumarate, Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-, (2E)-2-butenedioate (2:1) (salt)

Aliskiren hemifumarate (CAS 173334-58-2) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C64H110N6O16 and a molecular weight of 1219.59000 g/mol. Key property: a melting point of 72-75?C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 173334-58-2
Jingsj CID: J-1986973-9
Molecular Formula: C₆₄H₁₁₀N₆O₁₆
Molecular Weight: 1219.59000 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	72-75?C
Exact Mass	1218.80000
PSA	366.86000
LogP	9.88180
Vapor Pressure	1.59E-23mmHg at 25°C
Storage Conditions	Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Activity & Biological Data

Additional Information	[1]. Yuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med. Chem. Lett., 2012, 3 (9), pp 754–758 [2]. Buczko W, et al. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31. [3]. Wood JM, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor.Biochem Biophys Res Commun, 2003, 308(4), 698-705. [4]. Gradman AH, et al.Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation, 2005, 111(8), 1012-1018.

Additional Information

[1]. Yuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med. Chem. Lett., 2012, 3 (9), pp 754–758 [2]. Buczko W, et al. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31. [3]. Wood JM, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor.Biochem Biophys Res Commun, 2003, 308(4), 698-705. [4]. Gradman AH, et al.Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation, 2005, 111(8), 1012-1018.

Frequently Asked Questions

What is the CAS number of Aliskiren hemifumarate?

The CAS number of Aliskiren hemifumarate is 173334-58-2.

What are the molecular formula and molecular weight of Aliskiren hemifumarate?

Aliskiren hemifumarate has molecular formula C64H110N6O16 and molecular weight 1219.59000 g/mol.

What are the upstream and downstream products of Aliskiren hemifumarate?

For Aliskiren hemifumarate, Upstream Products: Fumaric acid, tert-butyl N-[(1S,2S,4S)-4-[(3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl]-2-hydroxy-1-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-methylhexyl]carbamate, Aliskiren; Downstream Products: Aliskiren.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Aliskiren hemifumarate (CAS 173334-58-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1986973-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.