Aliskiren Hydrochloride

Also known as: Aliskiren HCl, Aliskiren hydrochloride, AKN hydrochloride, Rasilez Hydrochloride, Tekturna Hydrochloride, (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide hydrochloride, (αS,γS,δS,zS)-δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,z-bis(1-methylethyl)benzeneoctanamide hydrochloride, 5(S)-amino-4(S)-hydroxy-2(S),7(S)-diisopropyl-8-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-octanoic acid [N-(2-carbamoyl-2,2-dimethyl-ethyl)]-amide hydrochloride

Aliskiren Hydrochloride (CAS 173399-03-6) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C30H54ClN3O6 and a molecular weight of 588.21900 g/mol. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 173399-03-6
Jingsj CID: J-1962134-2
Molecular Formula: C₃₀H₅₄ClN₃O₆
Molecular Weight: 588.21900 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Exact Mass	587.37000
PSA	146.13000
LogP	5.88700

Activity & Biological Data

Target	IC50: 1.5 nM (renin)[1]; 0.6 nM (human renin), 2 nM (marmoset renin), 80 nM (rat renin), 7 nM (dog renin), 11 nM (rabbit renin), 63 nM (guinea pig renin), 150 nM (pig renin)[2]
Additional Information	[1]. Yuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med. Chem. Lett., 2012, 3 (9), pp 754–758 [2]. Ferri N, et al. Aliskiren inhibits prorenin-induced human aortic smooth muscle cell migration. J Renin Angiotensin Aldosterone Syst. 2015 Jun;16(2):284-91. [3]. Wood JM, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun. 2003 Sep 5;308(4):698-705. [4]. Wang C, et al. Aliskiren targets multiple systems to alleviate cancer cachexia. Oncol Rep. 2016 Nov;36(5):3014-3022.

Target

IC50: 1.5 nM (renin)[1]; 0.6 nM (human renin), 2 nM (marmoset renin), 80 nM (rat renin), 7 nM (dog renin), 11 nM (rabbit renin), 63 nM (guinea pig renin), 150 nM (pig renin)[2]

Additional Information

[1]. Yuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med. Chem. Lett., 2012, 3 (9), pp 754–758 [2]. Ferri N, et al. Aliskiren inhibits prorenin-induced human aortic smooth muscle cell migration. J Renin Angiotensin Aldosterone Syst. 2015 Jun;16(2):284-91. [3]. Wood JM, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun. 2003 Sep 5;308(4):698-705. [4]. Wang C, et al. Aliskiren targets multiple systems to alleviate cancer cachexia. Oncol Rep. 2016 Nov;36(5):3014-3022.

Frequently Asked Questions

What is the CAS number of Aliskiren Hydrochloride?

The CAS number of Aliskiren Hydrochloride is 173399-03-6.

What are the molecular formula and molecular weight of Aliskiren Hydrochloride?

Aliskiren Hydrochloride has molecular formula C30H54ClN3O6 and molecular weight 588.21900 g/mol.

What are the upstream and downstream products of Aliskiren Hydrochloride?

For Aliskiren Hydrochloride, Upstream Products: tert-butyl N-[(1S,2S,4S)-4-[(3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl]-2-hydroxy-1-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-methylhexyl]carbamate; Downstream Products: Aliskiren hemifumarate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Aliskiren Hydrochloride (CAS 173399-03-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1962134-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.