Aliskiren

Also known as: CGP 60536, Rasilez, Tekturna, SPP 100, (2S,4S,5S,7S)-5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide

Aliskiren (CAS 173334-57-1) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C30H53N3O6 and a molecular weight of 551.758 g/mol. Key properties include a boiling point of 748.4±60.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 406.4±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 173334-57-1
Jingsj CID: J-1979979-2
Molecular Formula: C₃₀H₅₃N₃O₆
Molecular Weight: 551.758 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	748.4±60.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	406.4±32.9 °C
Exact Mass	551.393433
PSA	146.13000
LogP	2.74
Vapor Pressure	0.0±2.6 mmHg at 25°C
Refractive Index	1.514

Activity & Biological Data

Additional Information	[1]. Yuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med. Chem. Lett., 2012, 3 (9), pp 754–758 [2]. Buczko W, et al. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31. [3]. Wood JM, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor.Biochem Biophys Res Commun, 2003, 308(4), 698-705. [4]. Gradman AH, et al.Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation, 2005, 111(8), 1012-1018. [5]. Chang AY, et al. Interplay between brain stem angiotensins and monocyte chemoattractant protein-1 as a novel mechanism for pressor response after ischemic stroke. Neurobiol Dis. 2014 Nov;71:292-304.

Additional Information

[1]. Yuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med. Chem. Lett., 2012, 3 (9), pp 754–758 [2]. Buczko W, et al. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31. [3]. Wood JM, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor.Biochem Biophys Res Commun, 2003, 308(4), 698-705. [4]. Gradman AH, et al.Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation, 2005, 111(8), 1012-1018. [5]. Chang AY, et al. Interplay between brain stem angiotensins and monocyte chemoattractant protein-1 as a novel mechanism for pressor response after ischemic stroke. Neurobiol Dis. 2014 Nov;71:292-304.

Frequently Asked Questions

What is the CAS number of Aliskiren?

The CAS number of Aliskiren is 173334-57-1.

What are the molecular formula and molecular weight of Aliskiren?

Aliskiren has molecular formula C30H53N3O6 and molecular weight 551.758 g/mol.

What are the upstream and downstream products of Aliskiren?

For Aliskiren, Upstream Products: tert-butyl N-[(1S,2S,4S)-4-[(3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl]-2-hydroxy-1-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-methylhexyl]carbamate, Benzeneoctanamide, N-(3-amino-2,2-dimethyl-3-oxopropyl)-δ-azido-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-, Aliskiren hemifumarate; Downstream Products: Aliskiren hemifumarate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Aliskiren (CAS 173334-57-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1979979-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.