Bardoxolone

Also known as: CDDO, RTA 401, 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid, RTA-401, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid

Bardoxolone (CAS 218600-44-3) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C31H41NO4 and a molecular weight of 491.661 g/mol. Key properties include a boiling point of 632.9±55.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 336.6±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 218600-44-3
Jingsj CID: J-1986451-8
Molecular Formula: C₃₁H₄₁NO₄
Molecular Weight: 491.661 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	632.9±55.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	336.6±31.5 °C
Exact Mass	491.303558
PSA	95.23000
LogP	5.76
Vapor Pressure	0.0±4.0 mmHg at 25°C
Refractive Index	1.575
Storage Conditions	-20°C

Activity & Biological Data

Target	Nrf-2[1]
Additional Information	[1]. McCullough PA, et al. Cardiac and renal function in patients with type 2 diabetes who have chronic kidney disease: potential effectsof bardoxolone methyl. Drug Des Devel Ther. 2012;6:141-9. [2]. Hong DS, et al. A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas. Clin Cancer Res. 2012 Jun 15;18(12):3396-406. [3]. Reisman SA, et al. Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney. J Am Soc Nephrol. 2012 Oct;23(10):1663-73. [4]. Dinh CH, et al. Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice. ScientificWorldJournal. 2015;2015:549352.

Target

Nrf-2[1]

Additional Information

[1]. McCullough PA, et al. Cardiac and renal function in patients with type 2 diabetes who have chronic kidney disease: potential effectsof bardoxolone methyl. Drug Des Devel Ther. 2012;6:141-9. [2]. Hong DS, et al. A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas. Clin Cancer Res. 2012 Jun 15;18(12):3396-406. [3]. Reisman SA, et al. Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney. J Am Soc Nephrol. 2012 Oct;23(10):1663-73. [4]. Dinh CH, et al. Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice. ScientificWorldJournal. 2015;2015:549352.

Frequently Asked Questions

What is the CAS number of Bardoxolone?

The CAS number of Bardoxolone is 218600-44-3.

What are the molecular formula and molecular weight of Bardoxolone?

Bardoxolone has molecular formula C31H41NO4 and molecular weight 491.661 g/mol.

What are the upstream and downstream products of Bardoxolone?

For Bardoxolone, Upstream Products: Bardoxolone methyl, Methyl 3,12-dioxoolean-9(11)-en-28-oate; Downstream Products: 1,1-diphenyl-2-picrylhydrazine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Bardoxolone (CAS 218600-44-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1986451-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.