Monomethyl fumarate

Also known as: Fumaric acid monomethyl ester, Methyl hydrogen fumarate, (2E)-4-Methoxy-4-oxobut-2-enoic acid, (E)-2-Butenedioic acid hydrogen 1-methyl ester, mono-Methyl fumarate, MFCD00063174

Monomethyl fumarate (CAS 2756-87-8) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C5H6O4 and a molecular weight of 130.099 g/mol. Key properties include a melting point of 144-145ºC, a boiling point of 250.0±23.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 108.9±16.1 °C. It is classified under GHS with signal word Danger and hazard statements H318 — Causes serious eye damage. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 2756-87-8
Jingsj CID: J-1975935-4
Molecular Formula: C₅H₆O₄
Molecular Weight: 130.099 g/mol
Category: Organic Acids
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	144-145ºC
Boiling Point	250.0±23.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	108.9±16.1 °C
Exact Mass	130.026611
PSA	63.60000
LogP	-0.24
Vapor Pressure	0.0±1.1 mmHg at 25°C
Refractive Index	1.469

GHS Safety & Compliance

CorrosionSignal word: Danger

H318 — Causes serious eye damage

Activity & Biological Data

Additional Information	[1]. Tang H, et al. The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist. Biochem Biophys Res Commun. 2008 Oct 31;375(4):562-5. [2]. Jiang D, et al. Monomethyl Fumarate Protects the Retina From Light-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2019 Mar 1;60(4):1275-1285. [3]. Sghaier R, et al. Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrialalterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol. J Steroid Biochem Mol Biol. 2019 Nov;194:105432.

Additional Information

[1]. Tang H, et al. The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist. Biochem Biophys Res Commun. 2008 Oct 31;375(4):562-5. [2]. Jiang D, et al. Monomethyl Fumarate Protects the Retina From Light-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2019 Mar 1;60(4):1275-1285. [3]. Sghaier R, et al. Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrialalterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol. J Steroid Biochem Mol Biol. 2019 Nov;194:105432.

Customs & Trade Information

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Monomethyl fumarate?

The CAS number of Monomethyl fumarate is 2756-87-8.

What are the molecular formula and molecular weight of Monomethyl fumarate?

Monomethyl fumarate has molecular formula C5H6O4 and molecular weight 130.099 g/mol.

Is Monomethyl fumarate hazardous?

Monomethyl fumarate has GHS signal word Danger and hazard statements H318 — Causes serious eye damage.

What are the upstream and downstream products of Monomethyl fumarate?

For Monomethyl fumarate, Upstream Products: Monomethyl maleate, Dimethyl fumarate, Maleic anhydride; Downstream Products: 2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetic acid, methyl 2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetate, (2-Imino-4-oxo-1,3-thiazolidin-5-yl)acetic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Monomethyl fumarate (CAS 2756-87-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1975935-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.