Dimethyl fumarate

Also known as: dimethyl (E)-but-2-enedioate, fumaric acid dimethyl ester, DMF

Dimethyl fumarate (CAS 624-49-7) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C6H8O4 and a molecular weight of 144.125 g/mol. Key properties include a melting point of 102-106 °C(lit.), a boiling point of 193.0±0.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 91.1±0.0 °C. It is classified under GHS with signal word Warning and hazard statements H312 — Harmful in contact with skin, H315 — Causes skin irritation and H317 — May cause an allergic skin reaction. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 624-49-7
Jingsj CID: J-42157-8
Molecular Formula: C₆H₈O₄
Molecular Weight: 144.125 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	102-106 °C(lit.)
Boiling Point	193.0±0.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	91.1±0.0 °C
Exact Mass	144.042252
PSA	52.60000
LogP	0.62
Vapor Pressure	0.5±0.3 mmHg at 25°C
Refractive Index	1.435

GHS Safety & Compliance

Irritant / Environmental HazardSignal word: Warning

H312 — Harmful in contact with skin
H315 — Causes skin irritation
H317 — May cause an allergic skin reaction
H319 — Causes serious eye irritation
H411 — Toxic to aquatic life with long lasting effects

Activity & Biological Data

Additional Information	[1]. Albrecht P, et al. Effects of dimethyl fumarate on neuroprotection and immunomodulation. J Neuroinflammation. 2012 Jul 7;9:163 [2]. Peng H, et al. Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. J Biol Chem. 2012 Aug 10;287(33):28017-26. [3]. Meili-Butz S, et al. Dimethyl fumarate, a small molecule drug for psoriasis, inhibits Nuclear Factor-kappaB and reduces myocardial infarct size in rats. Eur J Pharmacol. 2008 May 31;586(1-3):251-8. [4]. Cross SA, et al. Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection. J Immunol. 2011 Nov 15;187(10):5015-25. [5]. Jing X, et al. Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity. Neuroscience. 2015 Feb 12;286:131-40 [6]. Li Y, et al. Dimethyl fumarate accelerates wound healing under diabetic condition. J Mol Endocrinol. 2018 Jul 23. pii: JME-18-0102.

Additional Information

[1]. Albrecht P, et al. Effects of dimethyl fumarate on neuroprotection and immunomodulation. J Neuroinflammation. 2012 Jul 7;9:163 [2]. Peng H, et al. Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. J Biol Chem. 2012 Aug 10;287(33):28017-26. [3]. Meili-Butz S, et al. Dimethyl fumarate, a small molecule drug for psoriasis, inhibits Nuclear Factor-kappaB and reduces myocardial infarct size in rats. Eur J Pharmacol. 2008 May 31;586(1-3):251-8. [4]. Cross SA, et al. Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection. J Immunol. 2011 Nov 15;187(10):5015-25. [5]. Jing X, et al. Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity. Neuroscience. 2015 Feb 12;286:131-40 [6]. Li Y, et al. Dimethyl fumarate accelerates wound healing under diabetic condition. J Mol Endocrinol. 2018 Jul 23. pii: JME-18-0102.

Customs & Trade Information

HS Code	2917190090
Summary	2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Dimethyl fumarate?

The CAS number of Dimethyl fumarate is 624-49-7.

What are the molecular formula and molecular weight of Dimethyl fumarate?

Dimethyl fumarate has molecular formula C6H8O4 and molecular weight 144.125 g/mol.

Is Dimethyl fumarate hazardous?

Dimethyl fumarate has GHS signal word Warning and hazard statements H312 — Harmful in contact with skin; H315 — Causes skin irritation; H317 — May cause an allergic skin reaction.

What are the upstream and downstream products of Dimethyl fumarate?

For Dimethyl fumarate, Upstream Products: tert-Butyl methyl ether, Fumaric acid, Dimethyl acetylenedicarboxylate; Downstream Products: Dimethyl trans-1,2-cyclohexanedicarboxylate, N-Nitrosodiethylamine, (-)-Dimenthyl fumarate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Dimethyl fumarate (CAS 624-49-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-42157-8 (accessed 2026-11-09).

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