trans-4-Hydroxy-D-proline hydrochloride

Also known as: (2R,4S)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride, (2R,4S)-(+)-4-Hydroxy-D-proline hydrochloride, (4S)-4-Hydroxy-D-proline hydrochloride, 4-(S)-Hydroxypyrrolidine-2-(R)-carboxylic acid hydrochloride, D-Hydroxyproline hydrochloride, D-trans-4-Hydroxyproline hydrochloride, NSC 206273 hydrochloride, trans-4-Hydroxy-D-proline HCl

trans-4-Hydroxy-D-proline hydrochloride (CAS 142347-81-7) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C5H10ClNO3 and a molecular weight of 167.591 g/mol. Key properties include a boiling point of 368.6ºC at 760mmHg and a flash point of 176.7ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 142347-81-7
Jingsj CID: J-1975164-5
Molecular Formula: C₅H₁₀ClNO₃
Molecular Weight: 167.591 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	368.6ºC at 760mmHg
Flash Point	176.7ºC
Exact Mass	167.034927
PSA	69.56000
Vapor Pressure	6.22E-07mmHg at 25°C

Activity & Biological Data

Target	Non-cleavable
Additional Information	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Frequently Asked Questions

What is the CAS number of trans-4-Hydroxy-D-proline hydrochloride?

The CAS number of trans-4-Hydroxy-D-proline hydrochloride is 142347-81-7.

What are the molecular formula and molecular weight of trans-4-Hydroxy-D-proline hydrochloride?

trans-4-Hydroxy-D-proline hydrochloride has molecular formula C5H10ClNO3 and molecular weight 167.591 g/mol.

What are the upstream and downstream products of trans-4-Hydroxy-D-proline hydrochloride?

For trans-4-Hydroxy-D-proline hydrochloride, Upstream Products: N-BOC-trans-4-hydroxy-D-proline methyl ester; Downstream Products: trans-4-Hydroxy-D-proline methyl ester hydrochloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "trans-4-Hydroxy-D-proline hydrochloride (CAS 142347-81-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1975164-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.