3,4,5-Trimethoxy-trans-cinnamic acid

Also known as: (2E)-3-(3,4,5-Trimethoxyphenyl)acrylic acid, (E)-3-(3,4,5-Trimethoxyphenyl)acrylic acid, (E)-3-(3,4,5-Trimethoxyphenyl)propenoic acid, (E)-6,7,8-trimethoxycinnamic acid, 2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)-, (2E)-, 3,4,5-Trimethoxycinnamic acid, 3,4,5-Trimethoxycinnamic_acid, 3-(3,4,5-Trimethoxyphenyl)acrylic acid, 3-(3,4,5-trimethoxyphenyl)prop-2-enoic acid, AKOS BBS-00000775, O-Methylsinapic acid, OTAVA-BB BB7119152925, RARECHEM BK HC T328, trans-3,4,5-Trimethoxycinnamic acid, Cinepazide Impurities4, Cinepazide Impurities1390

3,4,5-Trimethoxy-trans-cinnamic acid (CAS 20329-98-0) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C12H14O5 and a molecular weight of 238.237 g/mol. Key properties include a melting point of 125-127ºC(lit.), a boiling point of 396.4±37.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 151.5±20.0 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 20329-98-0
Jingsj CID: J-1973403-3
Molecular Formula: C₁₂H₁₄O₅
Molecular Weight: 238.237 g/mol
Category: Organic Acids
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	125-127ºC(lit.)
Boiling Point	396.4±37.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	151.5±20.0 °C
Exact Mass	238.084122
PSA	64.99000
LogP	2.00
Vapor Pressure	0.0±1.0 mmHg at 25°C
Refractive Index	1.560

Activity & Biological Data

Additional Information	[1]. Zhao Z, et al. Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives. Eur J Med Chem. 2019 Jul 1;173:213-227. [2]. Chen CY, et al. 3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice. J Pharmacol Sci. 2016 May;131(1):1-5. [3]. Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36(10):1244-51.

Additional Information

[1]. Zhao Z, et al. Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives. Eur J Med Chem. 2019 Jul 1;173:213-227. [2]. Chen CY, et al. 3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice. J Pharmacol Sci. 2016 May;131(1):1-5. [3]. Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36(10):1244-51.

Frequently Asked Questions

What is the CAS number of 3,4,5-Trimethoxy-trans-cinnamic acid?

The CAS number of 3,4,5-Trimethoxy-trans-cinnamic acid is 20329-98-0.

What are the molecular formula and molecular weight of 3,4,5-Trimethoxy-trans-cinnamic acid?

3,4,5-Trimethoxy-trans-cinnamic acid has molecular formula C12H14O5 and molecular weight 238.237 g/mol.

What are the upstream and downstream products of 3,4,5-Trimethoxy-trans-cinnamic acid?

For 3,4,5-Trimethoxy-trans-cinnamic acid, Upstream Products: 3,4,5-Trimethoxycinnamic acid ethyl ester, Malonic acid, 3,4,5-Trimethoxybenzaldehyde; Downstream Products: Piperlongumine, 3,4,5-Trimethoxycinnamic acid ethyl ester, 3-(3,4,5-Trimethoxyphenyl)propanoic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "3,4,5-Trimethoxy-trans-cinnamic acid (CAS 20329-98-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1973403-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.