Regorafenib hydrochloride

Also known as: Regorafenib (Hydrochloride), Regorafenib HCl, BAY 73-4506 hydrochloride, Regorafenib Hydrochloride (Standard), Regorafenib monohydrochloride, 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide hydrochloride, 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, hydrochloride (1:1)

Regorafenib hydrochloride (CAS 835621-07-3) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C21H16Cl2F4N4O3 and a molecular weight of 519.276 g/mol. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 835621-07-3
Jingsj CID: J-1971277-7
Molecular Formula: C₂₁H₁₆Cl₂F₄N₄O₃
Molecular Weight: 519.276 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Exact Mass	518.053589
PSA	95.84000
LogP	6.96830
Storage Conditions	2-8℃

Activity & Biological Data

Target	VEGFR1:13 nM (IC50) VEGFR2:4.2 nM (IC50) VEGFR3:46 nM (IC50) PDGFRβ:22 nM (IC50) Braf:28 nM (IC50) BRafV600E:19 nM (IC50) Raf-1:2.5 nM (IC50)
Additional Information	[1]. Wilhelm SM, et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer, 2011, 129(1), 245-255. [2]. Heng DY, et al. Targeted therapy for metastatic renal cell carcinoma: current treatment and future directions. Ther Adv Med Oncol, 2010, 2(1), 39-49. [3]. Carr BI, et al. Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery. J Cell Physiol, 2013, 228(2), 292-297.

Target

VEGFR1:13 nM (IC50) VEGFR2:4.2 nM (IC50) VEGFR3:46 nM (IC50) PDGFRβ:22 nM (IC50) Braf:28 nM (IC50) BRafV600E:19 nM (IC50) Raf-1:2.5 nM (IC50)

Additional Information

[1]. Wilhelm SM, et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer, 2011, 129(1), 245-255. [2]. Heng DY, et al. Targeted therapy for metastatic renal cell carcinoma: current treatment and future directions. Ther Adv Med Oncol, 2010, 2(1), 39-49. [3]. Carr BI, et al. Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery. J Cell Physiol, 2013, 228(2), 292-297.

Frequently Asked Questions

What is the CAS number of Regorafenib hydrochloride?

The CAS number of Regorafenib hydrochloride is 835621-07-3.

What are the molecular formula and molecular weight of Regorafenib hydrochloride?

Regorafenib hydrochloride has molecular formula C21H16Cl2F4N4O3 and molecular weight 519.276 g/mol.

What are the upstream and downstream products of Regorafenib hydrochloride?

For Regorafenib hydrochloride, Upstream Products: Regorafenib, 3-Fluoro-4-nitrophenol, 4-Amino-3-fluorophenol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Regorafenib hydrochloride (CAS 835621-07-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1971277-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.