Vortioxetine
Also known as: 1-(2-((2,4-Dimethylphenyl)thio)phenyl)piperazine, 1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine, 1-{2-[(2,4-Dimethylphenyl)sulfanyl]phenyl}piperazine, Lu AA 21004, Lu AA21004, Trintellix (vortioxetine), Vortioxetin
Vortioxetine (CAS 508233-74-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C18H22N2S and a molecular weight of 298.446 g/mol. Key properties include a boiling point of 424.8±45.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 210.7±28.7 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 508233-74-7
- Jingsj CID
- J-1958262-8
- Molecular Formula
- C18H22N2S
- Molecular Weight
- 298.446 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 424.8±45.0 °C at 760 mmHg |
|---|---|
| Density | 1.2±0.1 g/cm3 |
| Flash Point | 210.7±28.7 °C |
| Exact Mass | 298.150360 |
| PSA | 40.57000 |
| LogP | 4.26 |
| Vapor Pressure | 0.0±1.0 mmHg at 25°C |
| Refractive Index | 1.643 |
| Storage Conditions | 2-8°C |
Activity & Biological Data
| Target | 5-HT1A Receptor:15 nM (Ki) 5-HT1B Receptor:33 nM (Ki) 5-HT3A Receptor:3.7 nM (Ki) Human 5-HT7 Receptor:19 nM (Ki) SERT:1.6 nM (Ki) |
|---|---|
| Additional Information | [1]. Bang-Andersen B, Ruhland T, J?rgensen M, Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21. [2]. Guilloux JP, Mendez-David I, Pehrson A, Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice. Neuropharmacology. 2013 May 28;73C:147-159. [3]. Theunissen EL, Street D, H?jer AM, A randomized trial on the acute and steady-state effects of a new antidepressant, vortioxetine (Lu AA21004), on actual driving and cognition. Clin Pharmacol Ther. 2013 Jun;93(6):493-501. [4]. Rothschild AJ, Mahableshwarkar AR, Jacobsen P, Vortioxetine (Lu AA21004) 5mg in generalized anxiety disorder: results of an 8-week randomized, double-blind, placebo-controlled clinical trial in the United States. Eur Neuropsychopharmacol. 2012 Dec;22(12):858-66. [5]. M?rk A, Pehrson A, Brennum LT, Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder. J Pharmacol Exp Ther. 2012 Mar;340(3):666-75. |
Customs & Trade Information
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Vortioxetine?
The CAS number of Vortioxetine is 508233-74-7.
What are the molecular formula and molecular weight of Vortioxetine?
Vortioxetine has molecular formula C18H22N2S and molecular weight 298.446 g/mol.
What are the upstream and downstream products of Vortioxetine?
For Vortioxetine, Upstream Products: Vortioxetine hydrobromide, Piperazine, 1-[(2-Bromophenyl)thio]-2,4-dimethylbenzene; Downstream Products: Vortioxetine hydrobromide.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Vortioxetine (CAS 508233-74-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1958262-8 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.