Vortioxetine hydrobromide

Also known as: 1-[2-[(2,4-Dimethylphenyl)thio]phenyl]piperazine hydrobromide, 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine hydrobromide, 1-{2-[(2,4-Dimethylphenyl)sulfanyl]phenyl}piperazine hydrobromide (1:1), Lu AA21004 hydrobromide, Lu AA 21004 hydrobromide, Vortioxetine HBr, Vortioxetine (Lu AA21004) HBr, Vortioxetine hydrobromide, Vortioxetine monohydrobromide, Brintellix, UNII:TKS641KOAY, Piperazine, 1-[2-[(2,4-dimethylphenyl)thio]phenyl]-, hydrobromide (1:1)

Vortioxetine hydrobromide (CAS 960203-27-4) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C18H23BrN2S and a molecular weight of 379.358 g/mol. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 960203-27-4
Jingsj CID: J-1981-8
Molecular Formula: C₁₈H₂₃BrN₂S
Molecular Weight: 379.358 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Exact Mass	378.076538
PSA	40.57000
LogP	5.21610
Storage Conditions	-20°C

Activity & Biological Data

Target	5-HT1A Receptor:15 nM (Ki) 5-HT1B Receptor:33 nM (Ki) 5-HT3A Receptor:3.7 nM (Ki) 5-HT7 Receptor:19 nM (Ki) SERT:1.6 nM (Ki)
Additional Information	[1]. Bang-Andersen B, et al. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21. [2]. Guilloux JP, et al. Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice. Neuropharmacology. 2013 May 28;73C:147-159. [3]. Theunissen EL, et al. A randomized trial on the acute and steady-state effects of a new antidepressant, vortioxetine (Lu AA21004), on actual driving and cognition. Clin Pharmacol Ther. 2013 Jun;93(6):493-501. [4]. Rothschild AJ, Mahableshwarkar AR, Jacobsen P, Vortioxetine (Lu AA21004) 5mg in generalized anxiety disorder: results of an 8-week randomized, double-blind, placebo-controlled clinical trial in the United States. Eur Neuropsychopharmacol. 2012 Dec;22(12):858-66. [5]. Mork A, et al. Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder. J Pharmacol Exp Ther. 2012 Mar;340(3):666-75.

Target

5-HT1A Receptor:15 nM (Ki) 5-HT1B Receptor:33 nM (Ki) 5-HT3A Receptor:3.7 nM (Ki) 5-HT7 Receptor:19 nM (Ki) SERT:1.6 nM (Ki)

Additional Information

[1]. Bang-Andersen B, et al. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21. [2]. Guilloux JP, et al. Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice. Neuropharmacology. 2013 May 28;73C:147-159. [3]. Theunissen EL, et al. A randomized trial on the acute and steady-state effects of a new antidepressant, vortioxetine (Lu AA21004), on actual driving and cognition. Clin Pharmacol Ther. 2013 Jun;93(6):493-501. [4]. Rothschild AJ, Mahableshwarkar AR, Jacobsen P, Vortioxetine (Lu AA21004) 5mg in generalized anxiety disorder: results of an 8-week randomized, double-blind, placebo-controlled clinical trial in the United States. Eur Neuropsychopharmacol. 2012 Dec;22(12):858-66. [5]. Mork A, et al. Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder. J Pharmacol Exp Ther. 2012 Mar;340(3):666-75.

Frequently Asked Questions

What is the CAS number of Vortioxetine hydrobromide?

The CAS number of Vortioxetine hydrobromide is 960203-27-4.

What are the molecular formula and molecular weight of Vortioxetine hydrobromide?

Vortioxetine hydrobromide has molecular formula C18H23BrN2S and molecular weight 379.358 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Vortioxetine hydrobromide (CAS 960203-27-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1981-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.