Cariprazine hydrochloride

Also known as: Cariprazine HCl, RGH-188 hydrochloride, RGH 188 hydrochloride, Cariprazine (hydrochloride), Vraylar, Reagila, 3-[4-[2-[4-(2,3-Dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea hydrochloride, N'-[trans-4-[2-[4-(2,3-Dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-dimethylurea hydrochloride (1:1), UNII-KQD7C255YG

Cariprazine hydrochloride (CAS 1083076-69-0) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C21H33Cl3N4O and a molecular weight of 463.872 g/mol. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1083076-69-0
Jingsj CID: J-1956116-1
Molecular Formula: C₂₁H₃₃Cl₃N₄O
Molecular Weight: 463.872 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Exact Mass	462.171997
PSA	42.31000
LogP	5.34480
Storage Conditions	2-8°C

Activity & Biological Data

Target	Ki: 0.49 nM (D2 receptor), 0.085 nM (D3 receptor), 2.6 nM (5-HT1A receptor)[1]
Additional Information	[1]. Seneca N, et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl). 2011 Dec;218(3):579-8 [2]. Kiss B, et al. Cariprazine (RGH-188), a dopamine D(3) receptor-preferring, D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile. J Pharmacol Exp Ther. 2010 Apr;333(1):328-40. [3]. Zimnisky R, et al. Cariprazine, a dopamine D(3)-receptor-preferring partial agonist, blocks phencyclidine-induced impairments of working memory, attention set-shifting, and recognition memory in the mouse. Psychopharmacology (Berl). 2013 Mar;226(1):91-100. [4]. Gao Y, et al. Cariprazine exerts antimanic properties and interferes with dopamine D2 receptor β-arrestin interactions. Pharmacol Res Perspect. 2015 Feb;3(1):e00073. [5]. Citrome L. Cariprazine in schizophrenia: clinical efficacy, tolerability, and place in therapy. Adv Ther. 2013 Feb;30(2):114-26.

Target

Ki: 0.49 nM (D2 receptor), 0.085 nM (D3 receptor), 2.6 nM (5-HT1A receptor)[1]

Additional Information

[1]. Seneca N, et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl). 2011 Dec;218(3):579-8 [2]. Kiss B, et al. Cariprazine (RGH-188), a dopamine D(3) receptor-preferring, D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile. J Pharmacol Exp Ther. 2010 Apr;333(1):328-40. [3]. Zimnisky R, et al. Cariprazine, a dopamine D(3)-receptor-preferring partial agonist, blocks phencyclidine-induced impairments of working memory, attention set-shifting, and recognition memory in the mouse. Psychopharmacology (Berl). 2013 Mar;226(1):91-100. [4]. Gao Y, et al. Cariprazine exerts antimanic properties and interferes with dopamine D2 receptor β-arrestin interactions. Pharmacol Res Perspect. 2015 Feb;3(1):e00073. [5]. Citrome L. Cariprazine in schizophrenia: clinical efficacy, tolerability, and place in therapy. Adv Ther. 2013 Feb;30(2):114-26.

Frequently Asked Questions

What is the CAS number of Cariprazine hydrochloride?

The CAS number of Cariprazine hydrochloride is 1083076-69-0.

What are the molecular formula and molecular weight of Cariprazine hydrochloride?

Cariprazine hydrochloride has molecular formula C21H33Cl3N4O and molecular weight 463.872 g/mol.

What are the upstream and downstream products of Cariprazine hydrochloride?

For Cariprazine hydrochloride, Upstream Products: Cariprazine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Cariprazine hydrochloride (CAS 1083076-69-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1956116-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.