Cariprazine

Also known as: RGH-188, RGH 188, RGH188, Vraylar, UNII-F6RJL8B278, 3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea, N'-[trans-4-[2-[4-(2,3-Dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-dimethylurea, trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-N,N-dimethylcarbamoyl-cyclohexylamine, Urea, N'-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-dimethyl-, Cariprazine (USAN/INN)

Cariprazine (CAS 839712-12-8) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C21H32Cl2N4O and a molecular weight of 427.411 g/mol. Key properties include a boiling point of 600.1±55.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 316.7±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 839712-12-8
Jingsj CID: J-1957498-2
Molecular Formula: C₂₁H₃₂Cl₂N₄O
Molecular Weight: 427.411 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	600.1±55.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	316.7±31.5 °C
Exact Mass	426.195313
PSA	42.31000
LogP	5.18
Vapor Pressure	0.0±1.7 mmHg at 25°C
Refractive Index	1.595
Storage Conditions	-20°C

Activity & Biological Data

Target	Ki: 0.49 nM (D2 receptor), 0.085 nM (D3 receptor), 2.6 nM (5-HT1A receptor)[1]
Additional Information	[1]. Seneca N, et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl). 2011 Dec;218(3):579-8 [2]. Kiss B, et al. Cariprazine (RGH-188), a dopamine D(3) receptor-preferring, D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile. J Pharmacol Exp Ther. 2010 Apr;333(1):328-40. [3]. Zimnisky R, et al. Cariprazine, a dopamine D(3)-receptor-preferring partial agonist, blocks phencyclidine-induced impairments of working memory, attention set-shifting, and recognition memory in the mouse. Psychopharmacology (Berl). 2013 Mar;226(1):91-100 [4]. Gao Y, et al. Cariprazine exerts antimanic properties and interferes with dopamine D2 receptor β-arrestin interactions. Pharmacol Res Perspect. 2015 Feb;3(1):e00073.

Target

Ki: 0.49 nM (D2 receptor), 0.085 nM (D3 receptor), 2.6 nM (5-HT1A receptor)[1]

Additional Information

[1]. Seneca N, et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl). 2011 Dec;218(3):579-8 [2]. Kiss B, et al. Cariprazine (RGH-188), a dopamine D(3) receptor-preferring, D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile. J Pharmacol Exp Ther. 2010 Apr;333(1):328-40. [3]. Zimnisky R, et al. Cariprazine, a dopamine D(3)-receptor-preferring partial agonist, blocks phencyclidine-induced impairments of working memory, attention set-shifting, and recognition memory in the mouse. Psychopharmacology (Berl). 2013 Mar;226(1):91-100 [4]. Gao Y, et al. Cariprazine exerts antimanic properties and interferes with dopamine D2 receptor β-arrestin interactions. Pharmacol Res Perspect. 2015 Feb;3(1):e00073.

Frequently Asked Questions

What is the CAS number of Cariprazine?

The CAS number of Cariprazine is 839712-12-8.

What are the molecular formula and molecular weight of Cariprazine?

Cariprazine has molecular formula C21H32Cl2N4O and molecular weight 427.411 g/mol.

What are the upstream and downstream products of Cariprazine?

For Cariprazine, Upstream Products: Dimethylamine, Ethyl trans-2-[4-(Boc-amino)cyclohexyl]acetate, (trans-4-aminocyclohexyl)acetic acid; Downstream Products: Cariprazine hydrochloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Cariprazine (CAS 839712-12-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1957498-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.