Vonoprazan fumarate

Also known as: TAK-438, Vonaprazan, Vonoprazan Fumarate, Vonoprazan fumarate (TAK-438), AK-438, 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate, 1-[5-(2-Fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine (2E)-2-butenedioate (1:1), 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine, 1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-, (2E)-2-butenedioate (1:1)

Vonoprazan fumarate (CAS 1260141-27-2) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C21H20FN3O6S and a molecular weight of 461.463 g/mol. It is listed by 1 supplier; request a quote for pricing. Record last updated Aug 21, 2026.

CAS No.: 1260141-27-2
Jingsj CID: J-1974051-3
Molecular Formula: C₂₁H₂₀FN₃O₆S
Molecular Weight: 461.463 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Exact Mass	461.105682
PSA	146.97000
LogP	3.82910

Activity & Biological Data

Additional Information	[1]. Arikawa Y, et al. Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem, 2012, 55(9), 4446-4456. [2]. Hori Y, et al. 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther, 2010, 335(1), 231-238. [3]. Hori Y, et al. A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. J Pharmacol Exp Ther, 2011, 337(3), 797-804.

Additional Information

[1]. Arikawa Y, et al. Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem, 2012, 55(9), 4446-4456. [2]. Hori Y, et al. 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther, 2010, 335(1), 231-238. [3]. Hori Y, et al. A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. J Pharmacol Exp Ther, 2011, 337(3), 797-804.

Frequently Asked Questions

What is the CAS number of Vonoprazan fumarate?

The CAS number of Vonoprazan fumarate is 1260141-27-2.

What are the molecular formula and molecular weight of Vonoprazan fumarate?

Vonoprazan fumarate has molecular formula C21H20FN3O6S and molecular weight 461.463 g/mol.

Which suppliers offer Vonoprazan fumarate?

1 supplier(s) listed; request a quote for pricing.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Vonoprazan fumarate (CAS 1260141-27-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1974051-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.